Volatile organic compounds in e-cigarettes tied to changes vascular function, health - Healio

CHICAGO — Volatile integrated compounds that are recovered successful combustible cigaret and e-cigarettes were linked with acute changes successful vascular function, according to a survey presented astatine the American Heart Association Scientific Sessions.

Pod-based e-cigarette and accepted cigaret use was associated with accrued systolic BP, diastolic BP and bosom complaint and decreased flow-mediated dilation of the brachial artery, Sana Majid, MD, MS, postdoctoral chap astatine Boston University School of Medicine, and colleagues reported.

Volatile integrated compounds that are recovered successful combustible cigaret and e-cigarettes were linked with acute changes successful vascular function.
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“We were funny successful studying whether pod-based e-cigarette usage affects definite measures of bosom health. We recruited steadfast young adults who utilized either pod-based e-cigarettes oregon combustible cigarettes oregon were nonusers of baccy products,” Majid told Healio. “We recovered that pod-based e-cigarette users and combustible cigaret users had elevated systolic BP astatine baseline. Acute usage of these pod-based devices decreased flow-mediated dilation of the brachial artery and raised BP akin to combustible cigaret usage and to a greater grade than successful nonusers of baccy products. We besides recovered that definite chemicals recovered successful baccy fume and e-cigarette aerosols that we measured successful our survey participants were associated with adverse changes successful the vascular wellness measures of interest.”

Researchers recruited 106 adults with nary preexisting CVD oregon CV hazard factors from property 18 to 45 years (mean age, 27 years) astatine Boston University Medical School and the University of Louisville utilizing Craigslist ads, Boston University and University of Louisville pupil email posts and authorized nationalist postings.

Majid explained that participants brought their ain pod-based e-cigarette oregon baccy merchandise for usage for 10 minutes. Nonusers that were recruited “puffed” connected a regular straw for the aforesaid duration. BP and flow-mediated dilation of the brachial artery were measured earlier and aft usage and urine samples were collected aft 1 hr to measurement levels of volatile integrated compounds associated with cigaret fume and e-cigarette aerosol.

Among users of e-cigarettes, 64% were exclusive users and 37% reported ne'er utilizing combustible cigarettes.

Researchers reported that some e-cigarette users and accepted cigaret users had akin systolic BP astatine baseline to each different and higher compared with baccy nonusers (e-cigarette users, 121 mm Hg; accepted cigaret users, 121 mm Hg; nonusers, 112 mm Hg; P = .0004).

E-cigarette usage was associated with decreased flow-mediated dilation (–3.2%) and accrued systolic BP (mean increase, 6 mm Hg), diastolic BP (mean increase, 4 mm Hg) and bosom complaint (mean increase, 5 BPM), each akin compared with accepted cigaret usage (P = .83).

The observed changes successful vascular relation among users of e-cigarettes were greater compared with nonusers (P for flow-mediated dilation < .0001; P for systolic BP = .002; P diastolic BP = .003; P for bosom complaint < .0001) and remained accordant aft accommodation for age, enactment and race.

Levels of volatile integrated compounds recovered successful subordinate urine samples including acrylamide, acrylonitrile and crotonaldehyde were associated with changes successful measures vascular health, according to the presentation.

In addition, cultured endothelial cells were exposed to prime volatile integrated compounds to measure nitric oxide production.

Researchers observed reduced acetylcholine-stimulated nitric oxide accumulation successful quality aortic endothelial cells successful civilization exposed to acrylamide, acrylonitrile and crotonaldehyde.

“The alterations recovered successful our survey suggest that pod-based e-cigarettes adversely impact measures of vascular health,” Majid told Healio. “We are continuing to travel up with the survey participants to spot the semipermanent vascular effects of e-cigarette use. It is important to code caution with e-cigarettes, arsenic overmuch remains unknown.”

Reference:

• Use of e-cigarettes had antagonistic cardiovascular effects akin to smoking cigarettes. newsroom.heart.org/news/use-of-e-cigarettes-had-negative-cardiovascular-effects-similar-to-smoking-cigarettes. Published Oct. 31, 2022. Accessed Nov. 3, 2022.