First broad spatial atlas of steadfast quality insubstantial from aggregate organs, including multi-cell and azygous compartment solution utilizing some GeoMx and CosMx
SEATTLE, February 02, 2023--(BUSINESS WIRE)--NanoString Technologies, Inc. (NASDAQ: NSTG), a starring supplier of beingness subject tools for find and translational research, announced the motorboat of the Spatial Atlas of Human Anatomy (SAHA) initiative, successful collaboration with Weill Cornell Medicine, to make multicellular, single-cell, and sub-cellular maps of 30 non-diseased organs from a steadfast and divers colonisation of adults.
SAHA is simply a foundational effort to representation 250 cardinal cells astatine 2 spatial scales: full transcriptome of histological features (50 µm to 2 mm successful length) and 1,000 RNAs and 64 proteins astatine azygous compartment solution (50 nm solution crossed 1 cm2). The task volition found champion practices successful experimental design, information analysis, and information standards for high-content spatial investigation crossed aggregate quality organs astatine a full transcriptome and proteome level. The extremity is to make a broad unfastened source, spatial notation modular that tin beryllium accessed by researchers astir the globe to beforehand our cognition of spatial biology.
"The extremity is for SAHA to beryllium a foundational database that tin service arsenic a benchmark notation for spatial precision medicine. Comparing spatial datasets of assorted organs from aggregate ethnicities tin seizure the variability successful samples that researchers bash not presently understand," stated Chris Mason, Professor of Physiology and Biophysics, Weill Cornell Medicine. "The probe squad plans to amusement however spatial organ atlasing astatine aggregate scales tin beryllium utilized for uncovering unsocial insights into organ development, health, and cancer."
Dr. Mason volition beryllium presenting an overview of the SAHA survey connected Monday, February 6th astatine 6:10pm ET, astatine the Advances successful Genome Biology and Technology league successful Hollywood, FL.
The GeoMx® Digital Spatial Profiler (DSP) volition measurement the look of full transcriptomes matched to the nonstop signifier of functional and structural histological organ features. In addition, the 1,000-plex RNA profiles and 64-plex macromolecule profiles collected by the CosMx™ Spatial Molecular Imager (SMI) volition alteration the highest-ever subcellular solution single-cell maps of compartment types, lineage states, metabolic capacity, cellular neighborhoods, subcellular movements of organelles, portion besides detailing spatially resolved and caller ligand-receptor interactions.
"The SAHA information set, obtained astatine aggregate spatial scales, analyte classes, and plex-levels, represents the largest information acceptable of its benignant ever collected," said Joseph Beechem, SVP & CSO of NanoString. "This atlas volition alteration our knowing of however steadfast tissues are organized and relation and supply the instauration of knowing required to some dainty and diagnose illness states."
Variability is an important facet of biologic research. The samples, selected to beforehand aesculapian research, volition seizure variability crossed sexes and ancestries (European, African, Latin American, East Asian, and South Asian). All results volition beryllium made disposable to the technological assemblage done the SAHA information portal, including earthy and processed data.
SAHA is simply a collaborative effort with Weill Cornell Medicine’s Department of Pathology and Laboratory Medicine, Englander Institute for Precision Medicine, and the WorldQuant Initiative for Quantitative Prediction. It volition beryllium led by Drs. Chris Mason, Robert E. Schwartz, and Shauna L. Houlihan, and executed successful 2 phases implicit the adjacent 3 years. The probe volition analyse however NanoString’s spatial platforms tin synergize for unprecedented biologic insights.
Dr. Mason serves connected the Scientific Advisory Board and is simply a paid advisor to NanoString
About NanoString Technologies, Inc.
NanoString Technologies, a person successful spatial biology, offers an ecosystem of innovative find and translational probe solutions, empowering our customers to representation the beingness of biology. The GeoMx® Digital Spatial Profiler, cited successful much than 190 peer-reviewed publications, is simply a flexible and accordant solution combining the powerfulness of full insubstantial imaging with cistron look and macromolecule information for spatial full transcriptomics and proteomics from 1 FFPE slide. The CosMx™ Spatial Molecular Imager (SMI) is an FFPE-compatible, single-cell imaging level powered by spatial multiomics enabling researchers to representation azygous cells successful their autochthonal environments to extract heavy biologic insights and caller discoveries from 1 experiment. The AtoMx™ Spatial Informatics Platform (SIP) is simply a cloud-based informatics solution with precocious analytics and planetary collaboration capabilities, enabling almighty spatial biology insights anytime, anywhere. The instauration of our probe tools is our nCounter® Analysis System, cited successful much than 6,500 peer-reviewed publications, which offers a unafraid mode to easy illustration the look of hundreds of genes, proteins, miRNAs, oregon transcript fig variations, simultaneously with precocious sensitivity and precision.
For much information, sojourn www.nanostring.com.
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Contacts
Doug Farrell, NanoString
Vice President, Investor Relations & Corporate Communications
dfarrell@nanostring.com
Phone: 206-602-1768
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