What to know for NFL Week 10: Score picks, bold predictions, fantasy tips, key stats for every game

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  • ESPN staff

The Week 10 NFL schedule for the 2022 season is stacked with large matchups, and we've got you covered with what you request to cognize heading into the weekend. Our NFL Nation reporters bring america the biggest keys to each crippled and a bold prediction for each matchup.

Additionally, ESPN Stats & Information provides a large stat to cognize and a betting nugget for each contest, and our Football Power Index (FPI) goes wrong the numbers with a matchup standing (on a standard of 1 to 100) and a crippled projection. ESPN researcher Kyle Soppe hands retired adjuvant fantasy football intel, arsenic well. Finally, Seth Walder and Eric Moody springiness america last people picks for each game. Everything you privation to cognize is present successful 1 spot to assistance you get acceptable for a loaded play of NFL football.

Let's get into the afloat Week 10 slate, including Stefon Diggs' archetypal crippled against the Vikings since being traded, a large Cowboys-Packers matchup and a travel to Germany for Tom Brady. It each culminates with a "Monday Night Football" matchup betwixt the Commanders and the Eagles connected ESPN. (Game times are Sunday unless different noted.)

Jump to a matchup:
SEA-TB | CLE-MIA | MIN-BUF
NO-PIT | DET-CHI | DEN-TEN
JAX-KC | HOU-NYG | IND-LV
DAL-GB | ARI-LAR | LAC-SF
WSH-PHI

Thursday: CAR 25, ATL 15
Bye: CIN, NE, NYJ, BAL

Seahawks (6-3) astatine Buccaneers (4-5) -- Germany

9:30 a.m. ET | NFL Network | Spread: TB -2.5 (44.5)

What to ticker for: The Bucs conscionable snapped a three-game losing streak by defeating the Rams 16-13 successful premier clip portion the Seahawks are connected a four-game triumph streak and holding onto archetypal spot successful the NFC West. The Bucs won't spell precise acold successful what could beryllium Tom Brady's past play if they can't enactment up much points, but the Seahawks person fixed up the fourth-most touchdown passes connected the roadworthy this season. -- Jenna Laine

Bold prediction: Jordyn Brooks volition notch his archetypal vocation interception. The Seahawks aren't a blitz-heavy defence to statesman with, and due to the fact that Brady is getting the shot retired of his hands faster than immoderate different backmost this play (an NFL-low 2.40 seconds connected average), their crippled program volition absorption much connected sum than pressure. Brooks volition beryllium the beneficiary, picking disconnected Brady to nonstop the Seahawks to a triumph and a 7-3 grounds heading into their bye. -- Brady Henderson

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2:13

Stephen A. Smith explains wherefore Geno Smith and the Seahawks volition bushed the Buccaneers.

Stat to know: The Buccaneers are averaging 18 points per game, the fewest points by a Brady-led discourtesy done 9 games successful his career. The fewest points per crippled for a Brady squad done 10 games is 19.6 successful 2003 -- the Bucs would request to people 35 points connected Sunday to champion that mark.

Injuries: Seahawks | Buccaneers

What to cognize for fantasy: Tyler Lockett is known for his boom-and-bust production, but the Geno Smith acquisition has seemingly cured that. He has scored much than 13 points successful six games this season. See Week 10 rankings.

Betting nugget: Tampa Bay tin clinch the nether connected its play triumph full (11.5) with a loss. Seattle tin clinch the implicit connected its play triumph full (6) with a win. Read more.

Moody's pick: Buccaneers 24, Seahawks 20
Walder's pick: Seahawks 23, Buccaneers 20
FPI prediction: TB, 83.1% (by an mean of 11.3 points)

Matchup must-reads: NFL players, coaches with astir to summation oregon suffer successful 2022 ... Brady hits 100K passing yards, leads Bucs to last-minute win ... Irvin's NFL career: Five teams, Super Bowl ejection, more


Browns (3-5) astatine Dolphins (6-3)

1 p.m. ET | CBS | Spread: MIA -3.5 (48.5)

What to ticker for: Dolphins wide receiver Tyreek Hill topped the 1,000-yard people past week, and teammate Jaylen Waddle is 188 yards distant from doing the same. His vocation precocious is 171 yards, but surpassing that won't beryllium casual against a Browns defence that's allowed lone 3 100-yard receivers each season, nary since Week 5. -- Marcel Louis-Jacques

Bold prediction: Nick Chubb volition heap up a season-high rushing full connected the crushed against the league's 15th-ranked tally defence arsenic the Browns effort to support up with Miami's high-flying offense. Chubb, whose play precocious (141 yards) came successful the opener, is caller pursuing Cleveland's bye -- and his ascendant violative enactment should beryllium healthy, too. -- Jake Trotter

Stat to know: Hill and Waddle fertile archetypal and fifth, respectively, successful receiving yards this play and person 1,916 combined receiving yards this season. The Browns person allowed 11.96 yards per reception -- tied for the 4th astir successful the NFL.

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1:15

Stephania Bell is holding connected to Raheem Mostert contempt being outsnapped by Jeff Wilson Jr. successful his Dolphins debut.

Injuries: Browns | Dolphins

What to cognize for fantasy: In Dolphins wins this season, Waddle is averaging 22.6 phantasy points (103.5 receiving yards) per game. See Week 10 rankings.

Betting nugget: Cleveland games are 5-2-1 to the over, the highest implicit percent successful the league. All 4 Miami location games this play person gone nether the total. Read more.

Moody's pick: Dolphins 27, Browns 17
Walder's pick: Dolphins 30, Browns 20
FPI prediction: MIA, 60.5% (by an mean of 3.0 points)

Matchup must-reads: Browns CB Ward says he'll instrumentality vs. Dolphins ... Dolphins manager asked Bears QB Fields to halt running ... GM: Watson connected way to commencement Dec. 4 ... Dolphins winning shootouts with Tagovailoa and Hill, but is it sustainable?


Vikings (7-1) astatine Bills (6-2)

1 p.m. ET | Fox | Spread: BUF -3.5 (43.5)

What to ticker for: The Bills person won 7 consecutive location games dating backmost to past season, each by treble digits, but that streak volition beryllium connected the enactment successful a large mode with the Vikings coming to municipality arsenic winners of six consecutive one-score games. While the Bills volition beryllium hoping to bounce backmost aft a pugnacious nonaccomplishment to the Jets, they mightiness beryllium without Josh Allen (right elbow), who has not missed a crippled since 2018 and accounts for a league-high 82% of the Bills' yardage and 92% of their touchdowns. Backup Case Keenum has acquisition with Stefon Diggs from 2017 successful Minnesota, including the "Minneapolis Miracle." -- Alaina Getzenberg

Bold prediction: Justin Jefferson and Diggs volition harvester for much than 300 receiving yards. Diggs, who has 2 100-yard performances successful his past 3 games, volition beryllium fired up to play against his archetypal team. Jefferson is connected a large roll, having racked up 4 100-yard games successful his past five. (He reached 98 yards the different time.) Be acceptable for a large show of receiving firepower. -- Kevin Seifert

Stat to know: Allen has thrown 2 interceptions successful each of his past 2 games. The Vikings person forced 14 hostile turnovers this season, and person intercepted a walk successful 3 consecutive games, with 5 full interceptions implicit those 3 games.

Injuries: Vikings | Bills

What to cognize for fantasy: The Bills' discourtesy is phantasy friendly, yet Devin Singletary hasn't recovered the painted country successful 5 consecutive games (0 unreserved TDs connected 79 carries this season). See Week 10 rankings.

Betting nugget: Buffalo mislaid past week arsenic a 10.5-point favourite against the Jets. Teams coming disconnected a nonaccomplishment arsenic a double-digit favourite are 46-28-2 against the dispersed (ATS) successful the pursuing crippled implicit the past 20 seasons. Read more.

Moody's pick: Bills 34, Vikings 24
Walder's pick: Vikings 24, Bills 17
FPI prediction: BUF, 79.9% (by an mean of 9.8 points)

Matchup must-reads: How Hockenson learned the Vikings' discourtesy successful 4 days ... How trading Diggs became a monolithic win-win for Bills, Vikings


Saints (3-6) astatine Steelers (2-6)

1 p.m. ET | Fox | Spread: NO -2 (40)

What to ticker for: After a Week 9 bye, the Steelers participate the backmost fractional of the play rested and with antiaircraft reinforcements connected the way. Outside linebacker T.J. Watt and information Damontae Kazee are expected to beryllium activated disconnected injured reserve, but the squad could beryllium without antiaircraft extremity Larry Ogunjobi. Though the Steelers had a rocky 2-6 commencement to the season, Mike Tomlin is 11-4 aft the bye, including 5 consecutive wins since 2017. -- Brooke Pryor

Bold prediction: The Saints volition bounce backmost contempt a abbreviated week connected the road, but they'll bash it with a patchwork violative enactment (Andrus Peat and Erik McCoy are hurt) and without starting linebacker Pete Werner. That's due to the fact that the Saints won't beryllium facing a moving backmost and tin instrumentality vantage of rookie Kenny Pickett, who has been sacked 8 times (with 4 interceptions) successful the past 2 games. The Saints' defence volition get astatine slightest 3 sacks and look much similar the defence that unopen the Raiders retired vs. the defence that showed up against the Ravens. -- Katherine Terrell

Stat to know: Chris Olave leads each NFL rookies with 618 receiving yards this season. He could go the 3rd Saints rookie with 1,000-plus receiving yards (Michael Thomas with 1,137 successful 2016, Marques Colston with 1,038 successful 2006).

Injuries: Saints | Steelers

What to cognize for fantasy: Najee Harris averaged 70.6 unreserved yards and 17.7 phantasy points per crippled past season. This season, helium has 1 crippled with 70 rushing yards and has yet to wide 14 phantasy points successful a game. See Week 10 rankings.

Betting nugget: Mike Tomlin is 14-4-2 ATS arsenic a location underdog (13-7 outright), including 7-0-2 ATS implicit the past 5 seasons (7-2 outright). Read more.

Moody's pick: Steelers 24, Saints 23
Walder's pick: Saints 19, Steelers 16
FPI prediction: NO, 61.9% (by an mean of 3.6 points)

Matchup must-reads: Kamara proceeding successful artillery lawsuit continued again ... Watt 'optimistic' astir Sunday instrumentality for needy Steelers defense


Lions (2-6) astatine Bears (3-6)

1 p.m. ET | Fox | Spread: CHI -3 (48.5)

What to ticker for: Justin Fields acceptable the single-game regular-season rushing grounds for quarterbacks with 178 yards connected 14 attempts successful Week 9. Fields leads each quarterbacks with 42 scrambles for 411 yards, and the Bears big a Lions defence that has allowed the third-most rushing yards per crippled to opposing QBs. The Lions are coming disconnected a 15-9 triumph implicit part rival Green Bay and person not won consecutive games since the 2020 season. Chicago is looking for its archetypal triumph implicit an NFC North hostile aft losing to the Packers and Vikings earlier this season. -- Courtney Cronin

Bold prediction: Brothers Amon-Ra and Equanimeous St. Brown volition some people a touchdown successful the aforesaid game. The siblings person been talking trash each week astir the matchup successful the midst of their video crippled sessions. They could go the 3rd siblings successful league past to execute this feat during the Super Bowl era, and their father, John Brown, prepared them for this moment. It'll beryllium their 3rd clip facing each different arsenic NFL opponents. -- Eric Woodyard

Stat to know: The Lions are allowing 5.0 yards per rush, ranking 28th successful the NFL. They look a Bears onslaught that averages 5.4 yards per rush, 2nd successful the NFL.

Injuries: Lions | Bears

What to cognize for fantasy: Fields has not thrown for 200 yards successful immoderate of his past 4 games, but connected the backmost of much than 8 phantasy points with his legs successful each of those games, helium has finished each of those weeks arsenic a top-seven phantasy QB. See Week 10 rankings.

Betting nugget: Unders successful part games are 29-13-1 this season. Read more.

Moody's pick: Bears 34, Lions 28
Walder's pick: Bears 19, Lions 14
FPI prediction: CHI, 59.2% (by an mean of 2.6 points)

Matchup must-reads: 'Trash speech and bragging rights': St. Brown brothers look disconnected for 3rd time ... Fields sets regular-season rushing people for QB ... Lions came unneurotic aft tumultuous week ... Dolphins manager asked Bears QB Justin Fields to halt running


Broncos (3-5) astatine Titans (5-3)

1 p.m. ET | CBS | Spread: TEN -3 (38)

What to ticker for: The Titans' wide receivers didn't drawback a azygous walk past week and averaged 1.53 yards of separation, the worst by immoderate squad this season. This week Tennessee is facing Pat Surtain II, 1 of the apical screen corners successful the NFL. Titans violative coordinator Todd Downing has taken it upon himself to enactment the wideouts successful a amended presumption to get open. "There are things we tin bash to assistance out. We're ever looking for ways to effort to strategy those guys up," helium said. -- Turron Davenport

Bold prediction: Rookie choky extremity Greg Dulcich, successful conscionable the 4th crippled of his career, volition apical the 87 yards receiving helium had against the Jaguars successful London and volition people his 2nd touchdown of the season. Dulcich is simply a pugnacious matchup successful coverage, and the Titans person surrendered 5 touchdowns this play to choky ends, fullbacks oregon moving backs. That besides means Denver's caller arrival, moving backmost Chase Edmonds, volition person immoderate interaction successful the passing game. -- Jeff Legwold

Stat to know: The Broncos person the top-ranked passing defense, holding opponents to 165.8 passing yards per game, and person allowed lone 4 passing touchdowns. The Titans person failed to propulsion a passing touchdown successful 3 consecutive games.

Injuries: Broncos | Titans

What to cognize for fantasy: Derrick Henry's measurement is ne'er a question and The King has a 20-plus-yard interaction successful six consecutive games ... it doesn't look to substance who is nether center. See Week 10 rankings.

Betting nugget: Tennessee is 5-0 ATS against teams with losing records this season. Read more.

Moody's pick: Titans 23, Broncos 17
Walder's pick: Broncos 23, Titans 9
FPI prediction: TEN, 60.8% (by an mean of 3.1 points)

Matchup must-reads: Wilson: Won a batch successful Seattle without wristband ... 'I anticipation idiosyncratic gets unfastened soon': Titans person league-worst separation complaint successful Chiefs loss ... Writing mightiness person been connected the partition for Chubb trade


Jaguars (3-6) astatine Chiefs (6-2)

1 p.m. ET | CBS | Spread: KC -9.5 (50.5)

What to ticker for: The Chiefs are facing their 5th hostile presently ranked successful the apical 10 successful scoring defence successful the Jaguars, who are allowing 19.8 points per game. Their results person been mixed. They are 3-1 with 2 games of 40-plus points and 2 of precisely 20. But the Jaguars person faced conscionable 1 of the league's apical 10 scoring teams and nary hostile rather similar the Chiefs, who pb the NFL successful scoring astatine 30.4 points per crippled and are 2nd successful yards astatine 415. -- Adam Teicher

Bold prediction: Patrick Mahomes volition apical 350 yards passing. The Jaguars are rotating rookie Montaric Brown and seasoned Tre Herndon astatine the country spot other Tyson Campbell, truthful expect the Chiefs to people that spot often Sunday. This is the aforesaid defence that gave up 146 yards and 2 TDs receiving to Davante Adams successful the archetypal fractional past week, and portion Tyreek Hill is gone, the Chiefs are inactive explosive offensively (JuJu Smith-Schuster has 17 catches the past 2 games and Travis Kelce is sixth successful the NFL with 57 catches). -- Mike DiRocco

Stat to know: Travis Etienne Jr. has tally for 100 yards and 1 touchdown successful 3 consecutive games, and his 435 rushing yards earlier archetypal interaction is ranked 3rd astir successful the NFL. The Chiefs person a 25.8% tally halt triumph complaint this season, the worst successful the NFL, per ESPN metrics and NFL Next Gen Stats. They person allowed 5.3 yards per unreserved successful the past 4 games.

Injuries: Jaguars | Chiefs

What to cognize for fantasy: Since Week 6, lone 5 receivers person scored much phantasy points than Smith-Schuster. See Week 10 rankings.

Betting nugget: Kansas City is 0-4 ATS astatine location this season. Mahomes is 15-19 ATS successful his vocation astatine home, including 3-8 ATS successful his past 11 location games. Read more.

Moody's pick: Chiefs 31, Jaguars 21
Walder's pick: Chiefs 28, Jaguars 24
FPI prediction: KC, 84.2% (by an mean of 12.0 points)

Matchup must-reads: Jags QB Lawrence bounces back, but tin his productive play proceed against the Chiefs? ... Mahomes is the comeback king of the NFL ... Have the Chiefs ever relied much connected Mahomes?


Texans (1-6) astatine Giants (6-2)

1 p.m. ET | CBS | Spread: NYG -4.5 (41)

What to ticker for: The Texans person the league's worst tally defence (180.6 yards per game) by a wide margin. That's not perfect erstwhile facing Saquon Barkley and the Giants. New York has the NFL's fifth-ranked rushing onslaught (161.5 ypg) and Barkley has astatine slightest 70 yards connected the crushed successful 7 of 8 games. He's besides caller and healthier disconnected the bye week. -- Jordan Raanan

Bold prediction: The Texans person allowed the astir rushing yards successful the NFL (1,445), and they're facing the third-leading rusher successful the NFL successful Barkley (779). But the Texans volition yet fig retired their tally woes and clasp him nether 100 yards. -- DJ Bien-Aime

Stat to know: The Giants person a plus-31 scoring borderline successful the 2nd fractional of games this play -- ranking 4th successful the NFL -- however, their minus-25 scoring borderline successful the archetypal fractional ranks 24th.

Injuries: Texans | Giants

What to cognize for fantasy: Volume holds worth and Dameon Pierce has astatine slightest 20 carries oregon three-plus catches successful six consecutive games. See Week 10 rankings.

Betting nugget: New York is 6-2 ATS, tied for the champion people successful the league. Read more.

Moody's pick: Giants 23, Texans 13
Walder's pick: Giants 27, Texans 16
FPI prediction: NYG, 67.4% (by an mean of 5.1 points)

Matchup must-reads: Texans WR Brandin Cooks admits to frustration: Want to win ... Giants roster: Midseason strengths and weaknesses ... 'Things don't hap overnight': Texans trying to hole NFL's worst unreserved defence with Giants up next ... Giants' McKinney unsure he'll instrumentality successful '22 aft 'freak accident'


Colts (3-5) astatine Raiders (2-6)

4:05 p.m. ET | CBS | Spread: LV -4.5 (41)

What to ticker for: New Colts manager Jeff Saturday volition beryllium the large headline, since helium has ne'er coached a shot crippled supra the precocious schoolhouse level. But eyes volition besides beryllium connected the borderline rush. The Raiders fundamentally swapped retired Yannick Ngakoue for Chandler Jones successful the offseason. While Indianapolis has gotten a decent instrumentality connected Ngakoue, who was traded by Las Vegas for Rock Ya-Sin and has 4.5 sacks for the Colts, Las Vegas is inactive waiting for Jones -- who signed a three-year, $51 cardinal free-agent woody and has conscionable 0.5 sacks -- to interruption out. -- Paul Gutierrez

Bold prediction: Between the Colts' colossal violative struggles (league-worst 14.7 points per game) and unit upheaval (assistant Parks Frazier volition telephone plays for the archetypal clip successful his career), and the Raiders' unit losses (Hunter Renfrow and Darren Waller to injured reserve), this feels similar a crippled successful which the victor volition people 17 points oregon fewer. The Colts person scored 10, 16 and 3 points successful their past 3 games. -- Stephen Holder

Stat to know: The Colts are the lone squad this play to fertile successful the bottommost 5 successful walk unreserved triumph complaint (36.2%, ranked 29th) and walk artifact triumph complaint (49.7%, 30th), according to ESPN Analytics and NFL Next Gen Stats.

Injuries: Colts | Raiders

What to cognize for fantasy: Davante Adams opened past week with the astir first-quarter catches by a Raider since Jerry Rice (2002), not atrocious for a subordinate who was held to 3 yards the week anterior successful New Orleans. Yes, he's conscionable fine. See Week 10 rankings.

Betting nugget: Overs are 14-5-1 astatine Allegiant Stadium since it opened successful 2020. Read more.

Moody's pick: Raiders 27, Colts 20
Walder's pick: Raiders 34, Colts 12
FPI prediction: LV, 86.0% (by an mean of 12.9 points)

Matchup must-reads: Jeff Saturday impresses Colts players: 'I care' astir them ... Raiders to enactment Waller connected IR, root says ... Why the Colts fired Frank Reich, and what's next ... Raiders waive erstwhile first-rounder Abram


Cowboys (6-2) astatine Packers (3-6)

4:25 p.m. ET | Fox | Spread: DAL -4.5 (43)

What to ticker for: If Aaron Rodgers and the remainder of the Packers' discourtesy struggled against the Lions' shaky defense, what are the Cowboys going to bash to them, particularly considering each the uncertainty astir the presumption of their 2 champion violative linemen, David Bakhtiari and Elgton Jenkins? Dallas ranks archetypal successful sacks per dropback, walk unreserved triumph complaint and unit percentage. -- Rob Demovsky

Bold prediction: CeeDee Lamb volition person much than 100 yards receiving. The Cowboys person not had a 100-yard crippled from a wide receiver done the archetypal 8 games of the season, which is the archetypal clip since 1973 that's occurred. Lamb came adjacent with 97 yards vs. Washington earlier successful the play and had 3 different games with astatine slightest 75 yards. The Packers person allowed 2 receivers (Justin Jefferson and Stefon Diggs) to person much than 100 yards done the aerial this season. -- Todd Archer

Stat to know: Rodgers has thrown 7 interceptions this season, already his astir successful a play since 2016. The Cowboys person sacked the opposing QB astatine slightest 4 times successful 4 consecutive games.

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2:32

Stephen A. Smith blames Aaron Rodgers for not surviving up to his accustomed level of greatness this season.

Injuries: Cowboys | Packers

What to cognize for fantasy: Over the past 11 months, wide receiver Allen Lazard has scored successful 9 of 12 games. See Week 10 rankings.

Betting nugget: Dallas is 6-2 ATS, tied for the champion people successful the league Read more.

Moody's pick: Cowboys 21, Packers 20
Walder's pick: Cowboys 24, Packers 19
FPI prediction: DAL, 64.2% (by an mean of 4.3 points)

Matchup must-reads: Cowboys manager McCarthy is simply a Pittsburgh guy, but Green Bay remains 'a peculiar place' ... Why Rodgers' declaration limits Packers' options and what could travel next ... 'November is simply a immense month': Cowboys exit bye with 3 games successful 12 days ... Packers' Rodgers: Appreciation for Mike McCarthy has grown ... Cowboys' Mike McCarthy tries to downplay instrumentality to Lambeau Field


Cardinals (3-6) astatine Rams (3-5)

4:25 p.m. ET | Fox | Spread: LAR -1.5 (43.5)

What to ticker for: The Rams person dominated the Cardinals since Sean McVay was hired arsenic caput coach, going 10-1 against Arizona successful the regular season. That's the second-best grounds successful the Super Bowl epoch by a caput manager with astatine slightest 10 games played against a divisional opponent. -- Sarah Barshop

Bold prediction: With each of the Cardinals' issues connected the violative enactment -- their full interior is retired -- Aaron Donald volition person a tract time and volition sack Kyler Murray 4 times. Murray volition person to tally for his life, which volition pb to 75 rushing yards. -- Josh Weinfuss

Stat to know: The Rams person been outscored by 61 points successful the 4th fourth this play (the astir successful the NFL), and their 8 turnovers successful the 4th fourth besides pb the league.

Injuries: Cardinals | Rams

What to cognize for fantasy: If you were to task DeAndre Hopkins' 3 games this play for 16 games, we are talking 139 catches for 1,589 yards and 11 TDs. He's averaging a vocation champion 22.6 phantasy points per crippled and hasn't missed a beat. See Week 10 rankings.

Betting nugget: Los Angeles has gone nether the full successful 5 of its past six games. Arizona has gone implicit the full successful 3 consecutive games. Read more.

Moody's pick: Cardinals 24, Rams 13
Walder's pick: Rams 22, Cardinals 17
FPI prediction: LAR, 56.9% (by an mean of 2.0 points)

Matchup must-reads: Cardinals-Rams week a dicey household concern for Jeffersons ... Three things the Rams' discourtesy needs to fix ... Stafford placed successful concussion protocol


Chargers (5-3) astatine 49ers (4-4)

8:20 p.m. ET | NBC | Spread: SF -7 (45.5)

What to ticker for: The Chargers participate this crippled giving up a league-worst 5.71 yards per unreserved and conscionable mislaid Austin Johnson, the team's champion run-stopping antiaircraft lineman, to a season-ending genu injury. The Niners' tally crippled was inconsistent successful the archetypal 8 weeks, but with Christian McCaffrey successful the fold, it looks to beryllium connected the uptick. And the Niners are expected to get immoderate different cardinal players specified arsenic moving backmost Elijah Mitchell backmost from wounded this week, which means if the Chargers are going to triumph this one, they're going to person to find answers to hole that woeful tally defence successful a hurry. -- Nick Wagoner

Bold prediction: McCaffrey volition accumulate 200 all-purpose yards, including 150 rushing yards. The Chargers person struggled to halt the run, which includes giving up explosive plays connected the ground. Although it's a constituent of accent for improvement, that volition beryllium hard with Johnson -- their champion run-stopper -- connected injured reserve. The lone happening that could forestall McCaffrey from going chaotic is the instrumentality of teammate Deebo Samuel, who volition instrumentality distant immoderate of McCaffrey's touches. -- Lindsey Thiry

Stat to know: Austin Ekeler and McCaffrey fertile Nos. 1-2 successful games with astatine slightest 1 rushing TD and 1 receiving TD implicit the past 5 seasons.

Injuries: Chargers | 49ers

What to cognize for fantasy: Ekeler had a rushing touchdown and a receiving touchdown past week, the 4th clip helium has done truthful implicit his past 5 games. Here is the afloat database of players who person had 4 specified games successful a play aggregate times successful their career: Austin Ekeler. See Week 10 rankings.

Betting nugget: "Sunday Night Football" unders are 7-2 this play and 36-23-2 implicit the past 4 seasons. Prime-time unders are 17-10-1 this play and 65-45-2 implicit the past 4 seasons. Read more.

Moody's pick: 49ers 28, Chargers 17
Walder's pick: 49ers 26, Chargers 23
FPI prediction: SF, 75.3% (by an mean of 7.9 points)

Matchup must-reads: DT Johnson latest Bolt mislaid for season ... 'Mooney' has been money: Ward providing 49ers big-time country play ... NFL flexes Chargers-Chiefs Week 11 crippled to SNF ... Inside the Ravens-49ers 2013 New Orleans Super Bowl blackout


Commanders (4-5) astatine Eagles (8-0)

Monday, 8:15 p.m. ET | ESPN | Spread: PHI -11 (44)

What to ticker for: Jalen Hurts carved the Commanders up with the heavy shot successful their Week 3 matchup successful Washington, completing 5 passes of 20-plus yards en way to a 24-8 win. His 340 passing yards successful that crippled correspond a play high. The Commanders request to wage other attraction to choky extremity Dallas Goedert, who has 14 catches for 164 yards and a touchdown implicit the past 2 weeks. -- Tim McManus

Bold prediction: Washington's defence volition clasp the Eagles to their second-lowest yardage full and second-lowest constituent full of the season. The Eagles' fewest points scored is 20, and their lowest yardage full 268. Washington has defended the Eagles' tally crippled arsenic good arsenic anyone, holding them to their lowest full this play (72 astatine 2.40 per carry) successful Week 3. The cardinal volition beryllium slowing the passing game; DeVonta Smith burned them for 169 yards and a touchdown. In the ensuing 5 games, he's had lone 193. If Washington tin bounds A.J. Brown, it tin endanger the upset. -- John Keim

Stat to know: The Eagles haven't trailed successful the 2nd fractional this season, and they are the archetypal squad to triumph the turnover conflict successful each of their archetypal 8 games since the 1972 Steelers.

Injuries: Commanders | Eagles

What to cognize for fantasy: Hurts is cruising and has had nary issues with Washington during his past 3 starts against them (all wins): 8 full touchdowns, 850 walk yards and 102 unreserved yards. See Week 10 rankings.

Betting nugget: Three consecutive Philadelphia games person gone implicit the total. Six of Washington's past 7 games person gone nether the total. Unders are 4-0 erstwhile Washington plays teams with winning records this season. Read more.

Moody's pick: Eagles 35, Commanders 20
Walder's pick: Eagles 24, Commanders 10
FPI prediction: PHI, 83.5% (by an mean of 11.5 points)

Matchup must-reads: Heinicke's starts person been 'roller-coaster' thrust for Commanders ... Brown fined $10K for taunting Steelers ... Robinson cause scolds Commanders for AG retort

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