- RESEARCH HIGHLIGHT
- 26 October 2022
Craspase is simply a caller CRISPR instrumentality that cleaves macromolecule alternatively of DNA, and tin beryllium switched disconnected — which makes it a perchance safer enactment than accepted CRISPR successful the therapeutic setting.
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Karen O’Leary
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Karen O’Leary is an Associate Research Analysis Editor with Nature Medicine.
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The CRISPR–Cas strategy forms the ground of therapeutic cistron editing, whereby a usher RNA directs a DNA-cutting enzyme to a targeted cistron — usually a mutated 1 that produces a disease-causing protein. Although this exertion has revolutionized probe and gene-therapy fields alike, the imaginable for imperishable off-target effects connected DNA — though highly uncommon — is origin for concern.
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doi: https://doi.org/10.1038/d41591-022-00103-2
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