medwireNews: Study findings reported successful Rheumatology suggest that anti-Sjögren’s syndrome/scleroderma autoantigen 1 (SSSCA1) antibodies may warrant further probe arsenic a biomarker for crab hazard among patients with systemic sclerosis (SSc).
In their case–control survey of 414 people with SSc, Ami Shah and colleagues from Johns Hopkins University School of Medicine successful Baltimore, Maryland, USA, recovered that the 209 individuals with crab were importantly much apt to trial affirmative for anti-SSSCA1 antibodies connected an immunoprecipitation assay than the 205 without, astatine rates of 11% and 4%, respectively. This relation remained important aft accommodation for factors including sex, race, property astatine SSc onset, and smoking.
Among radical with cancer, the mean clip betwixt the archetypal non-Raynaud’s SSc grounds and crab onset was importantly longer among anti-SSSCA1-positive versus -negative patients (12.3 vs 6.9 years), portion the mean clip from the archetypal Raynaud’s oregon non-Raynaud’s grounds to crab diagnosis was numerically greater successful the anti-SSSCA1-positive radical (15.6 vs 11.4 years), albeit without reaching statistical significance.
“In the discourse of anterior information showing overexpression of SSSCA1 successful respective cancers,” these findings rise “the intriguing anticipation that anti-SSSCA1 antibodies could beryllium portion of a protective anti-tumor immune effect that delays crab emergence successful patients with SSc,” constitute Shah et al.
They conclude: “Future studies are warranted to validate these findings successful different SSc cohorts with well-defined crab status, to analyse the imaginable anti-tumor effects of anti-SSSCA1 immune responses, and to find whether SSSCA1 is highly expressed successful cancerous tissues from these patients.”
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