In a objective trial, non-nutritive sweeteners — which are supposedly inert — were shown to disrupt the gut microbiome of steadfast radical and impair glucose tolerance.
The replacement of sugar-sweetened beverages with non-nutritive sweetened beverages whitethorn lend to a simplification successful assemblage value and assemblage fat4, but concerns astir the toxicity of sweeteners and their interaction connected the encephalon were archetypal raised much than a decennary ago5. There is simply a astonishing irony successful the information that these sweeteners are present suspected of being progressive successful the deterioration of glucose tolerance — contempt their expected neutral interaction successful metabolic diseases.
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References
Andrade, L. et al. Nutr. Rev. 79, 1145–1164 (2021).
Carocho, M., Morales, P. & Ferreira, I. C. F. R. Food Chem. Toxicol. 107, 302–317 (2017).
Suez, J. et al. Cell 185, 3307–3328 (2022).
McGlynn, N. D. et al. JAMA Netw. Open 5, e222092 (2022).
Humphries, P., Pretorius, E. & Naudé, H. Eur. J. Clin. Nutr. 62, 451–462 (2008).
Wu, G. D. et al. Science 334, 105–108 (2011).
Suez, J. et al. Nature 514, 181–186 (2014).
Harpaz, D. et al. Molecules 23, 2454 (2018).
Kovatcheva-Datchary, P. et al. Cell Metab. 22, 971–982 (2015).
Daillère, R. et al. Immunity 45, 931–943 (2016).
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Le Roy, T., Clément, K. Bittersweet: artificial sweeteners and the gut microbiome. Nat Med (2022). https://doi.org/10.1038/s41591-022-02063-z
Published: 02 November 2022
DOI: https://doi.org/10.1038/s41591-022-02063-z
English (US)