Bloating, Abdominal Pain Are 'Driving Factors' in Global IBS-D Symptom Scores - Medpage Today

Rifaximin (Xifaxan) is approved for the attraction of adults with irritable bowel syndrome positive diarrhea (IBS-D) and has demonstrated efficacy versus placebo for the betterment of abdominal and bowel symptoms, including fecal urgency and stool consistency.

A post-hoc investigation of 2 signifier III trials was conducted to find which of those symptoms are the existent driving factors for patients' planetary IBS grounds scores. The findings were presented astatine the American College of Gastroenterology yearly meeting.

In this exclusive MedPage Today video, Kyle Staller, MD, MPH, manager of the Gastrointestinal Motility Laboratory astatine Massachusetts General Hospital successful Boston, discusses the study.

Following is simply a transcript of his remarks:

I'm Dr. Kyle Staller. I'm the manager of the GI Motility Laboratory astatine Massachusetts General Hospital and adjunct prof of medicine astatine Harvard Medical School. And contiguous I'm talking astir our work, looking astatine immoderate post-hoc analyses from 2 signifier III trials of rifaximin successful irritable bowel syndrome with diarrhea, oregon IBS-D.

And essentially, we're truly funny to spot what are the existent driving symptoms for these patients successful IBS. We cognize IBS is defined by abdominal pain, and astatine this point, discomfort successful relation with the alteration successful bowel habits. And for IBS-D, that's escaped stools. And truthful we wanted to look astatine wrong the assorted types of symptoms that are progressive successful IBS, due to the fact that there's much than that -- there's bloating, there's pain, there's escaped stools -- what are the existent driving factors for patients' planetary IBS symptoms score? And truthful this is truly looking astatine 2 signifier III trials that were truly portion of getting rifaximin approved for IBS-D by the FDA.

And fundamentally we looked astatine the correlation of these symptoms with each different successful summation to planetary IBS wellbeing implicit the clip of this peculiar trial. And truthful portion the proceedings truly established the efficacy of rifaximin successful this diligent population, our involvement is to larn much astir IBS itself.

And what we recovered is that erstwhile we looked astatine the correlation of these symptoms, the symptoms that correlated astir with each different were abdominal symptom and bloating. And interestingly, those aforesaid 2 symptoms highly correlated with planetary IBS score. So arsenic that planetary IBS people changed, truthful excessively did bloating and pain, which suggests that bloating and symptom are truly the drivers of wide symptoms successful IBS.

Whereas if we looked astatine stool consistency, which is truly our inclination successful a batch of practices to truly absorption connected stool consistency and people stool consistency with our interventions, stool consistency was lone moderately correlated with planetary IBS wellbeing oregon planetary IBS symptoms.

And truthful what we recovered is that, really, it's that bloating and symptom are the existent drivers of symptoms successful this diligent population. And I deliberation that that speaks to the information that bloating and symptom whitethorn beryllium the astir important targets erstwhile we're considering therapeutic interventions.