The American College of Neuropsychopharmacology (ACNP) volition grant Kristen J. Brennand, PhD, its 2022 Daniel H. Efron Research Award for outstanding basal probe contributions to neuropsychopharmacology.
The grant volition beryllium presented astatine ACNP’s 61st Annual Meeting December 4-7 successful Phoenix. It recognizes outstanding basal probe contributions to neuropsychopharmacology. The enactment of the awardee is based connected the prime of the publication and its interaction successful advancing neuropsychopharmacology.
Brennand is Elizabeth Mears and House Jameson Professor of Psychiatry and Genetics astatine Yale School of Medicine. She is simply a pioneer successful processing caller approaches to survey the biologic antecedents of quality psychiatric illness and has been recognized by galore foundations and societies for her outstanding technological contributions.
She was awarded the 2018 Maltz Prize for Innovative and Promising Schizophrenia Research by NARSAD, named a Brain and Behavior Research Foundation Scientific Council Member successful 2019, a subordinate of American College of Neuropsychopharmacology successful 2020, and a subordinate of the Connecticut Academy of Science and Engineering successful 2022.
She is besides an outstanding mentor to inferior scientists with a peculiar absorption connected promoting diverseness successful technological and aesculapian training. She established the Flex-Grad admissions process astatine the Icahn School of Medicine astatine Mount Sinai, an important recruitment pipeline for students of divers backgrounds, and is co-director of the recently launched Yale School of Medicine Fellows Program, a recruitment and grooming pathway for structured promotion to module for postdoctoral trainees from underrepresented backgrounds.
Brennand pioneered a caller attack to studying encephalon diseases, establishing that familial predisposition to psychiatric disorders ranging from schizophrenia to autism spectrum upset tin beryllium modeled utilizing patient-specific quality induced pluripotent stem cells (hiPSCs). Today, her laboratory successful the Yale Department of Psychiatry integrates hiPSC-based approaches with CRISPR-mediated genomic engineering strategies to survey the interaction of patient-specific DNA sequences crossed and betwixt the compartment types of the brain. This attack revealed that schizophrenia hazard variants person dynamic impacts that beryllium connected neuronal enactment and compartment type.
She besides discovered that DNA sequences associated with schizophrenia modulate genes that tin beryllium millions of bases distant done chromatin looping interactions. Many of her findings connected schizophrenia converge yet connected the relation of synapses, the connections betwixt neurons, and her enactment culminates successful robustly measurable effects adjacent successful DNA variants that confer lone one-percent accrued hazard of disease.
Submitted by Christopher Gardner connected November 28, 2022
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