1. In a systematic reappraisal and meta-analysis, children and adolescents with migraine are astatine higher hazard of anxiousness and slump symptoms and disorders compared with patients without migraines.
2. Pediatric patients with migraines whitethorn truthful payment from regular screening for anxiousness and depression.
Evidence Rating Level: 2 (Good)
Study Rundown: Migraines are communal successful children and adolescents and tin beryllium disabling for galore patients. Experts suggest that children with migraines whitethorn beryllium astatine an elevated hazard of anxiousness and depression, though high-quality studies confirming this relation are lacking. This systematic reappraisal and meta-analysis of 51 studies sought to measure if an relation betwixt migraine and anxiety/depressive symptoms exists. Meta-analysis suggested that migraines had a important relation with anxiousness symptoms, depressive symptoms, and higher likelihood of anxiousness and depressive disorders. Due to survey heterogeneity, systematic reappraisal could not measure whether having anxiousness and depressive symptoms oregon disorders impact migraine outcomes oregon incidence. An important regulation of this survey is the deficiency of controlling for covariates specified arsenic headache frequence and sex. In addition, astir studies included successful the meta-analysis reported lone unadjusted associations, thereby expanding hazard of confounding bias. Overall, this survey provides grounds that children with migraines are astatine accrued hazard for slump and anxiousness and should truthful acquisition regular screening for these symptoms and disorders.
Click present to work the nonfiction successful the JAMA Pediatrics
Relevant Reading: Prevalence of headache and migraine successful children and adolescents: a systematic reappraisal of population-based studies
In Depth [systematic reappraisal and meta-analysis]: This systematic reappraisal included each survey types with children < 18 years of property with migraines that assessed symptoms and disorders connected the spectrum of anxiousness disorders, depressive disorders, and trauma- and stressor-related disorders, according to the DSM-5. 80 studies were included successful the systematic review, and 51 were included successful the meta-analysis. Outcomes included symptoms and disorders of anxiety, depression, and mixed internalizing (anxiety and depression). Results of outcomes were stratified by signifier mounting including objective and community/population-based samples. Migraines had a statistical relation with anxiousness symptoms (standard mean quality [SMD] 1.13; 95% CI, 0.64-1.63) and depressive symptoms (SMD, 0.67; 95%CI, 0.46-0.87). In addition, children with migraines had higher likelihood of anxiousness (OR 1.93, 95% CI 1.49-2.50) and depressive disorders (OR 2.01, 95% CI 1.46-2.78). Outcomes did not disagree erstwhile results were stratified by signifier setting. There were 20 studies assessing the relation betwixt internalizing symptoms oregon disorders and migraine outcomes/severity, but heterogeneity of studies and outcomes precluded immoderate meta-analyses oregon conclusions.
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