Covid-19 vaccine study links side effects with greater antibody response - CNN

CNN  — 

People who reported experiencing broadside effects to the Pfizer/BioNTech and Moderna Covid-19 vaccines specified arsenic fever, chills oregon musculus symptom tended to person a greater antibody effect pursuing vaccination, according to caller research.

Having specified symptoms aft vaccination is associated with greater antibody responses compared with having lone symptom oregon rash astatine the injection tract oregon nary symptoms astatine all, suggests the insubstantial published Friday successful the journal JAMA Network Open.

“In conclusion, these findings enactment reframing postvaccination symptoms arsenic signals of vaccine effectiveness and reenforce guidelines for vaccine boosters successful older adults,” the researchers – from Columbia University successful New York, University of Vermont and Boston University – wrote successful their paper.

But adjacent though immoderate radical whitethorn person small, localized broadside effects oregon nary symptoms astatine all, the vaccine inactive elicits robust immune responses successful them too. Nearly each survey participants exhibited a affirmative antibody effect aft completing a two-dose Pfizer/BioNTech oregon Moderna vaccine series.

“I don’t privation a diligent to archer maine that, ‘Golly, I didn’t get immoderate reaction, my limb wasn’t sore, I didn’t person fever. The vaccine didn’t work.’ I don’t privation that decision to beryllium retired there,” said Dr. William Schaffner, a prof successful the Division of Infectious Diseases astatine Vanderbilt University Medical Center and aesculapian manager of the National Foundation for Infectious Diseases, who was not progressive successful the caller study.

“This is much to reassure radical who person had a absorption that that’s their immune strategy responding, really successful a alternatively bully way, to the vaccine, adjacent though it has caused them immoderate discomfort,” Schaffner said.

The researchers analyzed information connected 928 adults who self-reported what symptoms they experienced aft receiving Pfizer/BioNTech oregon Moderna Covid-19 vaccinations, arsenic good arsenic submitted a dried humor spot to trial for antibodies. Most of the participants were White adults, with a mean property of 65.

The researchers recovered that aft either vaccine dose, 446 oregon 48% of participants reported systemic symptoms portion 12% reported lone section symptoms and 40% reported nary symptoms astatine all.

Meanwhile, antibody reactivity was observed successful 444 oregon 99% of participants with systemic symptoms, 99% of those with lone section symptoms and 98% of those with nary symptoms.

“A batch of radical person speculated implicit the years whether radical who had much of a absorption to the vaccine mightiness really person that correspond a much vigorous immune response,” Schaffner said. “And these information would look to enactment that.”