1. For steadfast aged patients randomized to instrumentality low-dose aspirin for 4 weeks, determination was nary quality successful occurrence of fractures, but a higher occurrence of superior falls prompting hospitalization, compared to patients taking placebo.
Evidence Rating Level: 1 (Excellent)
For aged patients, falls and fractures are a large contributor to morbidity and mortality with 700,000 deaths associated with falls globally each year. Falls tin beryllium attributed to some biology and physiologic factors, specified arsenic bony strength. Although a systematic reappraisal has recovered an relation betwixt taking aspirin and little likelihood of fracture, this has not yet been investigated successful randomized controlled trials. Therefore, the ASPREE-FRACTURE survey was initiated successful Australia. This was a double-blind trial, comparing autumn and fracture outcomes for different steadfast individuals aged 70 and older, randomized to instrumentality low-dose 100 mg aspirin oregon placebo, for 4 weeks. The measured outcomes included prevalence of fracture and superior falls prompting presumption to hospital. In total, determination were 16,703 participants, 55.0% women, with 8,322 randomized to aspirin and 8,381 to placebo. The median (IQR) property was 74 (72-78) years, and the median follow-up was 4.6 years. The survey recovered 2,865 fractures and 1,688 superior falls. There was nary important quality successful the occurrence of archetypal fractures (hazards ratio 0.97, 95% CI 0.87-1.06, p = 0.50) oregon recurrent fractures (HR 0.96, 95% CI 0.87-1.06, p = 0.40). However, much individuals successful the aspirin radical experienced superior falls, with 750 (9.0%) compared to 687 (8.2%), which was importantly antithetic (incidence complaint ratio 1.17, 95% CI 1.03-1.33, p = 0.01). Overall, this survey demonstrated that steadfast aged patients taking low-dose aspirin had nary quality successful occurrence of fractures, but did person a importantly higher occurrence of superior falls.
Click to work the survey successful JAMA Internal Medicine
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