Electrical Neuromodulation Device Shows Promise as Nonpharmacological Alternative for Chronic Migraine - Pharmacy Times

The Nerivio (Theranica) distant electrical neuromodulation (REN) instrumentality showed akin outcomes to standard-of-care medications successful patients with chronic migraine, according to information from a station hoc survey analysis.1The findings bespeak that REN whitethorn connection a nonpharmacological attraction alternate for patients who endure from chronic migraine, according to the survey authors.^1,2

"Chronic migraine is an particularly disabling condition, diagnosed erstwhile a migraine diligent experiences astatine slightest 15 migraine-induced headache days per month,” said superior researcher Brian Grosberg, MD, director, Hartford Healthcare Headache Program, successful a property release.¹ "The recent Consensus Statement of the American Headache Society recommends that, successful bid to debar medicine overuse, patients with migraine who request to usage acute treatments connected a regular ground should beryllium instructed to bounds medicine usage to an mean of 2 headache days per week."

The FDA approved Nerivio successful October 2020 arsenic the archetypal smartphone-controlled prescribed wearable instrumentality for the acute attraction of migraine. Nerivio has since been approved for the acute attraction of episodic and chronic migraine successful big and teen patients. At the commencement of a migraine attack, the REN device, which is worn connected the precocious arm, triggers an endogenous analgesic mechanics called conditioned symptom modulation.

Among 78 patients with chronic migraine, 62.8% of those administered REN experienced important single-treatment symptom alleviation wrong 2 hours of initiating attraction compared with 48.7% of patients administered modular attraction (P = .056). Further, 64.1% of patients successful the REN cohort achieved changeless symptom alleviation vs 57.7% of patients successful the standard-care medications (P = .369) cohort.

Single-treatment symptom alleviation was achieved successful 23.1% of patients with chronic migraine fixed Nerivio compared with 19.2% of patients successful the modular medicine cohort (P = .532). Further, REN and modular of attraction medications produced 14.1% consistency of symptom state crossed aggregate treatments (P = 1.00).

In a dual-arm survey published in Pain Medicine, the operation of the Nerivio instrumentality with Nerivio’s Guided Imagery, Education and Relaxation (GIER) optional in-app behavioral involution led to a greater proportionality of patients experiencing accordant symptom alleviation and improved symptoms of their acute migraine versus attraction with REN attraction alone.^3,4

The researchers evaluated 85 patients with migraine who were astatine slightest 18 years of property and who treated their attacks with REN successful parallel with the GIER involution (REN+GIER) and individually matched them connected property and enactment with 85 patients who utilized REN alone. At 2 hours post-treatment, the REN+GIER radical displayed statistically importantly higher proportionality of patients achieving accordant symptom alleviation (P = .008), accordant betterment successful relation (P = .014), and accordant instrumentality to mean relation (P = .005) than the REN-only group.

"Chronic migraine patients often person 4, 5, oregon adjacent 6 headache days per week. To dainty them efficaciously and safely we indispensable grow the first-line standard-care attraction options beyond prescribed medications,” Grosberg said successful the release. “This probe provides a beardown examination of REN to prescribed medications, chiefly triptans, reinforcing the decision that REN provides a much-needed alternate to standard-care acute migraine treatment—without compromising effectiveness."¹

References
1. New survey suggests REN comparable to modular attraction prescribed medications for acute attraction of chronic migraine. News release. Theranica. September 19, 2022. Accessed September 30, 2022. https://www.prnewswire.com/news-releases/new-study-suggests-ren-comparable-to-standard-care-prescribed-medications-for-acute-treatment-of-chronic-migraines-301626947.html
2. Grosberg B, Rabany L, Vizel M, et al. Effectiveness examination of distant electrical neuromodulation and standard-care medications for acute attraction of chronic migraine: a post-hoc analysis. Pain Manag. 2022;12(7):837-844. doi:10.2217/pmt-2022-0053.
3. Peer-reviewed survey shows affirmative interaction of Nerivio’s Guided Imagery, Education, and Relaxation (GIER) diagnostic connected migraine attraction response. News release. Theranica. February 16, 2022. Accessed February 18, 2022. https://www.prnewswire.com/news-releases/peer-reviewed-study-shows-positive-impact-of-nerivios-guided-imagery-education-and-relaxation-gier-feature-on-migraine-treatment-response-301483460.html

4. Buse DC, Rabany L, Lin T, Ironi A, Connelly MA, Bickel JL. Combining guided involution of acquisition and relaxation (GIER) with distant electrical neuromodulation (REN) successful the acute attraction of migraine. Pain Med. Published online February 11, 2022. doi:10.1093/pm/pnac021