A molecular diligent database for Sjögren’s syndrome (SjS) and systemic lupus erythematosus (SLE) is to beryllium generated pursuing a concern with a German university.
Evotec SE made the announcement yesterday (Tuesday) that it volition enactment with Hannover Medical School (MHH).
The strategical concern betwixt Evotec and MHH aims astatine achieving a amended knowing of SjS and SLE by creating a longitudinal PanOmics database from the investigation of diligent material.
Biospecimens from respective 100 SjS and SLE patients volition beryllium collected by MHH and analyzed connected Evotec’s PanOmics platform, which includes genomics, transcriptomics, proteomics, and metabolomics arsenic good arsenic single-cell sequencing technologies.
Pseudonymized diligent information
Together with supplementary pseudonymized diligent data, these PanOmics information volition provender into Evotec’s proprietary translational molecular diligent information level E.MPD, which serves arsenic the cardinal information repository for molecular diligent data.
For world research, MHH volition person entree to the information generated wrong the concern by moving with Evotec’s artificial quality (AI)-driven analytics bundle PanHunter.
Evotec has the exclusive close to exploit the information commercially with its capabilities successful the tract of data-driven precision medicine. No fiscal presumption of the collaboration were disclosed.
Key illness drivers
Cord Dohrmann, main technological serviceman of Evotec, said: “We are excited to participate this concern with MHH and grow Evotec’s E.MPD database into autoimmune diseases. The accepted symptomatic statement of galore diseases stands successful the mode of some diagnosis and effectual treatment.
“By leveraging PanOmics data, we are taking a deeper dive into underlying illness mechanisms. A amended knowing of molecular illness mechanisms guides the recognition of cardinal illness drivers and yet supports the recognition of caller targets and the improvement of effectual medicine.”
Torsten Witte is simply a prof of rheumatology and caput of section of rheumatology and immunology astatine MHH. He said that truthful acold determination are nary efficacious anti-inflammatory therapies for Sjögren’s syndrome and lone fewer for SLE.
Autoimmune diseases
He said: “The recognition of inflammatory pathways contributing to the pathogenesis of the disorders would assistance to found caller therapies. Since these pathways whitethorn disagree inter-individually, the probe task by MHH and Evotec whitethorn adjacent pave the roadworthy to individualized treatments of Sjögren’s syndrome and SLE.
“We are truthful excited astir the possibilities of the collaboration that combines the expertise of the partners from MHH successful the nonstop objective characterization of the patients and from Evotec successful the exertion of multi-omics technologies.”
Sjögren’s Syndrome and systemic lupus erythematosus are among the astir communal forms of rheumatic autoimmune diseases. However, the chartless triggers and symptoms betwixt patients makes aboriginal diagnosis of these conditions a challenging process, often spanning respective years – a question besides addressed by the RESIST clump – a consortium of scientists from a scope of disciplines and institutions moving unneurotic connected a probe task astatine an internationally competitory level.
Despite important probe enactment successful the field, not overmuch is known astir the causes and progression of either disease, truthful presently disposable attraction regimens are symptomatic and supportive.
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