The Howard Hughes Medical Institute is committing $100 cardinal to a caller Emerging Pathogens Initiative to enactment basal probe targeted astatine preparedness for emerging pathogens that could endanger quality wellness successful the future. Thirteen task teams involving 70 scientists from 29 institutions volition collaborate connected the research.
“We are optimistic that this inaugural volition assistance these scientists make new, untested approaches that tin uncover however pathogens enactment and however the quality immune strategy responds to pathogen infection,” said HHMI Vice President and Chief Scientific Officer Leslie Vosshall. “With this program, we anticipation to summation immoderate of the cognition and tools we request to get a technological caput commencement connected aboriginal epidemics.”
During the COVID pandemic, galore successful the planetary technological assemblage learned arsenic overmuch arsenic they could – arsenic accelerated arsenic they could – astir the underlying SARS-CoV-2 virus. Labs retooled, researchers stretched successful caller directions, shared accusation openly, and began caller collaborations to amended recognize a deadly pathogen that was rapidly evolving. The technological assemblage besides began engaging much broadly with questions astir oversight of probe connected existing and imaginable pathogens and however to marque definite this important enactment is done arsenic safely arsenic possible.
As immoderate HHMI labs began shifting their attraction to COVID, HHMI launched a probe pilot, investing $35 cardinal successful 4 collaborative probe projects aimed astatine knowing much astir COVID and SARS-CoV-2. That enactment motivated the Institute to bash more.
“We were excited by the thought of catalyzing this collaborative probe connected a larger standard – focusing connected caller approaches to knowing the biology of emerging pathogens and the interactions of the quality immune strategy with infections to further the basal subject needed for accelerated and durable responses to aboriginal pandemics,” said HHMI Senior Scientific Officer Dennis McKearin.
Last year, HHMI announced plans to judge proposals for the recently created Emerging Pathogens Initiative, a programme that volition tally for 3 years with a extremity of accelerating probe into the origins, mechanisms, and improvement of emerging pathogens that could endanger quality health. This one-time contention invited proposals from HHMI Investigators for projects to beryllium conducted independently oregon successful collaboration with a divers spectrum of scientists astatine US institutions and crossed the globe. The 13 projects selected impact 70 scientists astatine 29 institutions. They tackle timely questions, including implications for diagnostics, therapeutics, and vaccines against a wide scope of worrisome pathogens.
HHMI is the largest backstage biomedical probe instauration successful the nation. Our scientists marque discoveries that beforehand quality wellness and our cardinal knowing of biology. We besides put successful transforming subject acquisition into a creative, inclusive endeavor that reflects the excitement of research. HHMI’s office are located successful Chevy Chase, Maryland, conscionable extracurricular Washington, DC.
Focus area: Akkermansia muciniphila arsenic a mucosal vaccine level for emerging pathogens
Lead Investigator: Gregory Barton, HHMI, University of California, Berkeley
Collaborators
Russell Vance, HHMI, University of California, Berkeley
Raphael H. Valdivia, Duke University
Lauren Davey, University of Victoria
Aaron Schmidt, Harvard Medical School and the Ragon Institute of MGH, MIT, and Harvard
Focus area: Developing modular, multifunctional therapeutics from “parts lists” for a wide spectrum of RNA viruses
Lead Investigator: Carolyn R. Bertozzi, HHMI, Stanford University
Collaborators
Taia Wang, Stanford University
Christopher Barnes, Stanford University
Peter S. Kim, Stanford University
Focus area: Infectious illness vaccines that bash not straight people microbes
Lead Investigator: Richard A. Flavell, HHMI, Yale University
Collaborators
George Dimopoulos, Johns Hopkins Bloomberg School of Public Health
Erol Fikrig, Yale University
Maudry Laurent Rolle, Yale University
Aaron Ring, Yale University
Photini Sinnis, Johns Hopkins Bloomberg School of Public Health
Drew Weissman, University of Pennsylvania
Heidi J. Zapata, Yale School of Medicine
Focus area: Targeting compartment envelope biosynthesis successful Borrelia for diagnostics, therapeutics, and vaccine find
Lead Investigator: Christine Jacobs-Wagner, HHMI, Stanford University
Collaborators
Laura M.K. Dassama, Stanford University
Naima G. Sharaf, Stanford University
Steven Banik, Stanford University
Ansuman Satpathy, Stanford University School of Medicine
Focus area: Pathogenic encephalon states: cells and circuits progressive successful altered encephalon relation aft non-central tense strategy infection
Lead Investigator: Michelle Monje, HHMI, Stanford University
Collaborators
Akiko Iwasaki, HHMI, Yale University
Beth Stevens, HHMI, Boston Children’s Hospital
Karl Deisseroth, HHMI, Stanford University
Erin Gibson, Stanford University
Catherine Blish, Stanford University
Shane Liddelow, New York University
Ukpong Eyo, University of Virginia
Focus area: Decoding the mitochondrial proteomes of six pathogenic protozoa
Lead Investigator: Vamsi K. Mootha, HHMI, Massachusetts General Hospital
Collaborators
John Samuelson, Boston University
Inna Afasizheva, Boston University
Ruslan Afasizhev, Boston University
Manoj Duraisingh, Harvard T.H. Chan School of Public Health
Namrata Udeshi, Broad Institute of MIT and Harvard
Luke Chao, Massachusetts General Hospital
Focus area: Targeting indispensable surface-accessible processes of bacterial gut pathogens with designed peptides
Lead Investigator: Joseph D. Mougous, HHMI, University of Washington
Collaborators
Gaurav Bhardwaj, University of Washington
Ana A. Weil, University of Washington
Focus area: Elucidating rapidly evolving virulence factors and their functions from bacterial pathogens
Lead Investigator: Kim Orth, HHMI, The University of Texas Southwestern Medical Center
Collaborators
Josephine Ni, The University of Texas Southwestern Medical Center
Tamia Harris-Tryon, The University of Texas Southwestern Medical Center
Qian Cong, The University of Texas Southwestern Medical Center
Kevin Forsberg, The University of Texas Southwestern Medical Center
Focus area: Merging the technologies of RNA biology and enhanced biosafety to make adjacent procreation wide spectrum RNA-based antiviral therapies
Lead Investigator: Anna Marie Pyle, HHMI, Yale University
Collaborators
Elke Mühlberger, Boston University National Emerging Infectious Disease Laboratories
Anthony Griffiths, Boston University National Emerging Infectious Disease Laboratories
Daniel Cifuentes, Boston University
Gustavo Mostoslavsky, Boston University
Focus area: Natural merchandise find for combating emerging pathogens
Lead Investigator: Benjamin Tu, HHMI, The University of Texas Southwestern Medical Center
Collaborators
Yi Tang, University of California, Los Angeles
Hosea M. Nelson, California Institute of Technology
Jue D. (Jade) Wang, University of Wisconsin–Madison
Jose A. Rodriguez, University of California, Los Angeles
Focus area: Investigating and engineering the avian and quality antibody effect to people emerging influenza viruses
Lead Investigator: Wilfred A. van der Donk, HHMI, University of Illinois Urbana-Champaign
Collaborators
Beth Stadtmueller, University of Illinois Urbana-Champaign
Nicholas Wu, University of Illinois Urbana-Champaign
Angad P. Mehta, University of Illinois Urbana-Champaign
Jenna Guthmiller, University of Colorado Anschutz Medical Campus
Focus area: Exploiting circadian rhythms successful anti-parasite immunity
Lead Investigator: Russell Vance, University of California, Berkeley
Collaborator
Filipa Rijo-Ferreira, University of California, Berkeley
Focus area: Building a toolbox for individualized jumbo-phage therapy against antibiotic-resistant infections
Lead Investigator: Elizabeth Villa, HHMI, University of California, San Diego
Collaborators
Kevin D. Corbett, University of California, San Diego
John Glass, J. Craig Venter Institute
Justin Meyer, University of California, San Diego
Kit Pogliano, University of California, San Diego
Joe Pogliano, University of California, San Diego
David Pride, University of California, San Diego
Paul Turner, Yale University
English (US)