High Blood Pressure Medication Shown To Slow Aging and Extend Lifespan - SciTechDaily

Researchers person discovered that the hypertension cause rilmenidine tin widen lifespan and dilatory aging.

New probe findings, published connected January 20 successful the diary Aging Cell, amusement that animals treated with rilmenidine, presently utilized to dainty hypertension (high humor pressure), astatine young and older ages summation lifespan and amended wellness markers, mimicking the effects of caloric restriction. Rilmenidine, which is simply a medicine medication, is marketed nether the marque names Albarel, Hyperium, Iterium, and Tenaxum. 

They besides show that the healthspan and lifespan benefits of rilmenidine attraction successful the roundworm C. elegans are mediated by the I1-imidazoline receptor nish-1, identifying this receptor arsenic a imaginable longevity target.

Unlike different drugs antecedently studied for this intent by the researchers, the widely-prescribed, oral antihypertensive rilmenidine has the imaginable for aboriginal translatability to humans arsenic broadside effects are uncommon and non-severe.

To date, a caloric regularisation fare has been considered the astir robust anti-aging intervention, promoting longevity crossed species. However, studies of caloric regularisation successful humans person had mixed results and broadside effects, meaning uncovering medications similar rilmenidine that tin mimic the benefits of caloric regularisation is the astir tenable anti-aging strategy.

Professor João Pedro Magalhães, who led the probe whilst astatine the University of Liverpool and is present based astatine the University of Birmingham, said: “With a planetary aging population, the benefits of delaying aging, adjacent if slightly, are immense. Repurposing drugs susceptible of extending lifespan and healthspan has a immense untapped imaginable successful translational geroscience. For the archetypal time, we person been capable to amusement successful animals that rilmenidine tin summation lifespan. We are present keen to research if rilmenidine whitethorn person different objective applications.”

Reference: “Rilmenidine extends lifespan and healthspan successful Caenorhabditis elegans via a nischarin I1-imidazoline receptor” by Dominic F. Bennett, Anita Goyala, Cyril Statzer, Charles W. Beckett, Alexander Tyshkovskiy, Vadim N. Gladyshev, Collin Y. Ewald and João Pedro de Magalhães, 20 January 2023, Aging Cell.
DOI: 10.1111/acel.13774

This survey was undertaken by researchers from the University of Liverpool, ETH Zürich, and Harvard Medical School, and funded by the Swiss National Science Foundation, LongeCity, and the Biotechnology and Biological Sciences Research Council.