How likely is a superfungus apocalypse? The science behind The Last of Us explained - The Telegraph

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If you benignant ‘zombie ants’ into a hunt motor you should brace yourself for a nasty surprise. You’ll find videos showing the industrious small critters becoming possessed, controlled and yet torn isolated by a fungus called Cordyceps.

Its spores bash not termination immediately; alternatively they prehend power of the ant from within, marching them up trees and shoots to wherever determination is airy and warmth capable for the fungus to multiply. Finally, successful scenes reminiscent of the sci-fi movie Alien, the fungus bursts from the ant’s exhausted corpse, raining caller spores onto its steadfast colleagues below. 

In this way, a azygous zombie idiosyncratic ant tin beryllium utilized by the cunning Cordyceps fungus to hitch retired an full colony. 

When I archetypal stumbled crossed 1 of these videos connected Twitter a fewer years backmost I was sceptical. Moulds whitethorn discolour the shower-room grout from clip to clip and, yes, Boots does merchantability a just spot of antifungal cream. But a fungus infecting a surviving carnal and past forcing it to bash its bidding? It each sounded a spot unlikely.

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But it is true; zombie ants possessed by fungi truly are a thing. One of the archetypal to study connected the improvement was Sir David Attenborough successful a movie broadcast by BBC Earth immoderate 14 years ago. It shows the Cordyceps fungus infecting the “bodies and minds” of slug ants successful a South American jungle. Worse than that – overmuch worse – is that galore different taxon crook retired to beryllium vulnerable. “There are virtually thousands of antithetic types of Cordyceps fungi and, remarkably, each specialises connected conscionable 1 species”, says Sir David ominously.

Now leap to The Last of Us, a TV adaptation of the eponymous video game which, accidental its makers, was inspired by the Attenbourgh documentary. Playing a scientist, the histrion John Hannah sets the country successful the opening moments of occurrence one: bacteria and viruses airs a menace to humanity but it’s fungi we should beryllium astir acrophobic of. “Fungi look harmless capable but galore taxon cognize otherwise,” helium says. “Viruses tin marque america sick but fungi tin change our minds.” 

With the sciencey spot over, it’s not agelong earlier the granny who lives adjacent doorway to the Texan hero, Joel, and his teenage daughter, Sarah, becomes possessed with Cordyceps and has to beryllium enactment down by means of a stroke to the caput with a hefty tube wrench. 

Is the Last of Us a load of aged hokum oregon could it, similar the 2011 movie Contagion, beryllium horribly prescient? 

The fungus 'Cordyceps' makes the leap into humans successful The Last of Us Credit: Liane Hentscher

Fortunately, Cordyceps cannot infect humans contiguous and is highly improbable ever to bash so. Unlike insects, america warm-blooded mammals are excessively blistery for it to get a due grip. The aforesaid goes for the immense bulk of the millions of fungal taxon retired there. However, determination are fungi that regularly infect and termination humans, and scientists are becoming progressively acrophobic astir them. As The Telegraph reported successful October, the World Health Organization (WHO) has warned of an “increasing fungal threat” and precocious published its first-ever database of fungal “priority pathogens” – a listing of the 19 fungi that it believes correspond the top menace to quality health.

“Fungal pathogens are a large menace to nationalist wellness arsenic they are becoming progressively communal and resistant to treatment, with lone 4 classes of antifungal medicines presently available,” says the wellness agency. “Most fungal pathogens deficiency accelerated and delicate diagnostics and those that beryllium are not wide disposable oregon affordable globally.”

Dr Hanan Balkhy, WHO adjunct director-general, antimicrobial resistance, adds: “Fungal infections are growing, and are ever much resistant to treatments, becoming a nationalist wellness interest worldwide.” 

Invasive fungal infections airs the astir information to severely sick patients and others with immune strategy disorders. Those astatine top hazard see patients undergoing organ transplants and those with cancer, HIV/Aids and chronic respiratory diseases. Nevertheless, the Global Action Fund for Fungal Infections estimates that much than 300 cardinal radical are afflicted with a superior fungal corruption each year, portion 1.6 cardinal dice annually. A further 25 cardinal are astatine precocious hazard of dying oregon losing their sight, it says. Infections aren’t confined by geography, with debilitating fungal outbreaks recorded crossed the world, including the UK. 

In November past year, a coroner described the decease of an “engaging, lively and endearing” two-year-old from prolonged vulnerability to mould successful his family’s Rochdale level arsenic a “defining moment” for the UK lodging sector. Awaab Ishak died 8 days aft his 2nd birthday from terrible granulomatous tracheobronchitis, wherever immune cells signifier clumps successful the lungs arsenic they combat an invading toxin oregon infection. 

His information was caused implicit months by breathing successful fungal spores emanating from the communal achromatic mould connected the walls of the bath and room of the lodging relation level helium lived in.

Awaab Ishak died aft months of breathing successful fungal spores emanating from the mould connected the walls of the lodging relation level helium lived in Credit: PA

“Action to dainty and forestall the mould was not taken,” said the coroner Joanne Kearsley. There are respective types of achromatic mould communal successful the UK including Aspergillus Niger, Alternaria and Cadosporium. It is not known what strain Awaab ingested.

Terrible scenes besides unfolded successful India successful 2021 erstwhile – during a immense question of Covid cases –  a fungus called Mucormycosis started preying connected susceptible infirmary patients, sidesplitting an estimated 4,300 radical and maiming galore more. The Telegraph covered the lawsuit of 38-year-old lawyer Vikram Trivedi who contracted the terrifying bug. Surgeons had to chopped retired his near eye, a ample portion of his sinus and the extortion of his rima successful a hopeless bid to prevention his beingness and forestall the fungus reaching his brain. 

“We ne'er thought thing similar this would hap to Vikram. He did value grooming and went jogging each day. He was successful precise bully health,” Ashwini Kadam, Trivedi’s wife, told the Telegraph astatine the time.

A diligent successful the Mucormycosis ward astatine Mumbai’s JJ Hospital Credit: Simon Townsley

Like each bully thrillers, The Last of Us contains different grains of truth. Fungi can, arsenic it suggests, be dispersed via concern nutrient stores, for example. In August 1951, 1 successful 20 of the 4,000 inhabitants of Pont-Saint-Esprit, a colony successful confederate France, were stuck down with hallucinations, vomiting and a unspeakable burning sensation connected their limbs. They were suffering from St Anthony’s Fire, an unwellness that was communal successful the Middle Ages and is caused by the Ergot fungus. In this case, the fungus contaminated the rye flour utilized successful making the villagers’ bread. 

“Ergot contains a chemic that makes the sufferers spell berserk and causes gangrene of the hands and feet owed to constriction of humor proviso to the extremities”, notes a statement of the incidental connected Medicine.net. “If it is not treated (and this was not imaginable successful the Middle Ages) victims had the sensation of being burned astatine the stake, earlier their fingers, toes, hands and feet dropped off”.

There is besides grounds that the incidence and geographic scope of fungal diseases are expanding. For example, the Candida fungus, which causes communal infections specified arsenic oral and vaginal thrush, has go progressively resistant to attraction and much widespread. Only this month, a drug-resistant mutation of the bug was recovered successful Mississippi for the archetypal time. The highly contagious corruption tin origin terrible unwellness successful radical with weakened immune systems and has dispersed wide crossed America implicit the past decade.

“This is the archetypal clip we’ve had a locally acquired lawsuit successful Mississippi,” says Bhagyashri Navalkele, an subordinate prof successful the UMMC Division of Infectious Diseases. “The nationalist needs to beryllium alert that we are seeing this fungus.”

When classifying cases, wellness officials person to separate betwixt “infections” and “colonisations”. This raises the imaginable of isolation, adjacent lockdowns. “Colonisation means you could beryllium a soundless bearer of the fungus,” says Dr Navalkele. “If you are identified arsenic colonised, you request to marque definite that your healthcare squad knows astir this truthful that they tin instantly commencement isolation precautions and initiate due attraction erstwhile corruption is suspected.”

And the bully news? So acold nary known fungal corruption has been linked to zombie-ism.


The Last of Us continues connected Sky Atlantic and Now TV tonight, Monday January 23

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