Hypertension drug can extend lifespan and slow aging - News-Medical.Net

Researchers person recovered that the cause rilmenidine tin widen lifespan and dilatory aging.

Published successful Aging Cell, the findings amusement that animals treated with rilmenidine, presently utilized to dainty hypertension, astatine young and older ages increases lifespan and improves wellness markers, mimicking the effects of caloric restriction.

They besides show that the healthspan and lifespan benefits of rilmenidine attraction successful the roundworm C. elegans are mediated by the I1-imidazoline receptor nish-1, identifying this receptor arsenic a imaginable longevity target.

Unlike different drugs antecedently studied for this intent by the researchers, the widely-prescribed, oral antihypertensive rilmenidine has imaginable for aboriginal translatability to humans arsenic broadside effects are uncommon and non-severe.

To date, a caloric regularisation fare has been considered the astir robust anti-aging intervention, promoting longevity crossed species. However, studies of caloric regularisation successful humans person had mixed results and broadside effects, meaning uncovering medications similar rilmenidine that tin mimic the benefits of caloric regularisation is the astir tenable anti-aging strategy.

Professor João Pedro Magalhães, who led the probe whilst astatine the University of Liverpool and is present based astatine the University of Birmingham, said: "With a planetary aging population, the benefits of delaying aging, adjacent if slightly, are immense. Repurposing drugs susceptible of extending lifespan and healthspan has a immense untapped imaginable successful translational geroscience. For the archetypal time, we person been capable to amusement successful animals that rilmenidine tin summation lifespan. We are present keen to research if rilmenidine whitethorn person different objective applications."

This survey was undertaken by researchers from the University of Liverpool, ETH Zürich and Harvard Medical School, and funded by the Swiss National Science Foundation, LongeCity and the Biotechnology and Biological Sciences Research Council.