Nearly 150 serious infections that failed to respond to antibiotics occurred per time past twelvemonth successful England - with experts informing "we are already seeing absorption emerge" to adjacent the newest drugs.
Infections caused by antibiotic-resistant bacteria are "killing thousands" successful the UK each twelvemonth and is not a occupation "we tin ignore", wellness officials said.
Figures from the UK Health Security Agency (UKHSA) showed determination was an mean of 148 terrible antibiotic-resistant infections per time successful 2021, up by 2.2% connected the erstwhile pandemic twelvemonth (53,985, up from 52,842).
Overall corruption numbers were inactive down connected pre-pandemic levels, but the UKHSA said this was driven by things specified arsenic reduced societal mixing and other handwashing.
The usage of antibiotics - which assistance substance antimicrobial absorption (AMR) - besides fell by 15% betwixt 2017 and 2021.
AMR occurs erstwhile bacteria, viruses, fungi and parasites mutate and nary longer respond to the medicines - including antibiotics - that are designed to dainty them.
This makes the illnesses precise hard to dainty and increases the hazard of diseases spreading, causing terrible unwellness and death.
Antibiotic absorption occurs naturally, but the overuse of antibiotics tin velocity up the process.
Professor Dame Jenny Harries, main enforcement of the UKHSA, said: "Antibiotic absorption is not a distant occupation that we tin ignore.
"Infections caused by antibiotic-resistant bacteria are sidesplitting thousands of radical each twelvemonth successful this state and globally, arsenic good arsenic having a immense economical impact.
"As we look from the COVID-19 pandemic, this is simply a pivotal infinitesimal to support absorption connected the 'silent pandemic' of antibiotic resistance."
Professor Susan Hopkins, main aesculapian advisor astatine the UKHSA, said: "We are already seeing absorption look to our precise newest antibiotics - innovation to find caller treatments volition lone win if we usage what we person responsibly.
"Overuse of antibiotics volition mean they halt moving against life-threatening conditions specified arsenic sepsis.
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"Antibiotics won't assistance the symptoms of cold, flu oregon COVID-19 - delight spot your healthcare professional, instrumentality antibiotics lone arsenic prescribed, ne'er stock with others and don't prevention for later.
"Taking antibiotics erstwhile you don't request them puts you and your loved ones astatine hazard of having an untreatable corruption successful future."