Both rates of macular vas density nonaccomplishment and ganglion compartment analyzable thinning are associated with cardinal ocular tract nonaccomplishment successful eyes with aboriginal glaucoma.
New probe published successful Ophthalmology suggests rates of macular vas density (VD) and ganglion compartment analyzable thinning (GCC) are associated with cardinal ocular tract nonaccomplishment implicit clip successful eyes with early glaucoma.
“Assessment of some macular VD and GCC thickness should beryllium considered for valuation of glaucoma progression,” wrote survey researcher Vahid Mohammadzadeh, MD, Department of Ophthalmology, UCLA Jules Stein Eye Institute.
Mohammadzadeh and a squad of colleagues investigated the narration of longitudinal changes successful macular vas density from optical coherence tomography (OCT) angiography and successful ganglion compartment analyzable (GCC) from OCT with cardinal VF successful this diligent population.
The observational cohort consisted of 95 eyes.Of the eyes, 37 were preperimetric and 58 were aboriginal glaucoma ( 10–2VF mean deviation [MD], ≥ –6 decibels) They had an mean follow-up of 3.8 years and an mean of 5.3 visits.
The investigators matched whole-image VD (wiVD) and whole-image GCC (wiGCC) and parafoveal scans, arsenic good arsenic localized regions of interest, hemiretinae of full images, and superior, inferior, temporal, and nasal sectors of parafoveal maps with cardinal VF location. Additionally, they calculated age-adjusted rates of alteration of VD, GCC, mean sensitivity of VF locations, and 10-2 VF MD utilizing linear mixed-effects models, arsenic good arsenic normalized rates of alteration for examination of alteration rates successful wiVD and wiGCC.
The main outcomes for the proceedings were the structure–function (SF) correlations of VD and GCC with cardinal VF measurement alteration rates and the examination of antithetic correlations of structure–function relationships aft bootstrapping the quality of the correlation coefficients.
Investigators observed vas density nonaccomplishment and GCC thinning exhibited important correlations with cardinal VF damage, globally and with astir localized regions of interest. Data amusement the structure–function correlation betwixt wiVD and 10–2 VF MD alteration rates was 0.42 (95% assurance interval [CI], 0.24 - 0.58). Meanwhile, the correlation was 0.27 (95% CI, 0.08 - 0.45) betwixt wiGCC and 10–2 VF MD alteration rates (all P <.05).
Moreover, successful opposition to GCC thinning, investigators recovered VD nonaccomplishment successful the parafoveal sectors exhigited important correlations with cardinal VF harm successful inferior and temporal sectors. They noted the differences successful the narration of structure-function with cardinal VF harm were not important betwixt VD nonaccomplishment and GCC thinning.
The information additionally amusement the mean normalized alteration rates of wiVD (–7.40%/year [95% CI, –7.71 to 7.09]) was faster compared to that of wiGCC (–2.39%/year [95% CI, –2.94 to 1.84]; P <.05).
The abstract, “Longitudinal Structure–Function Relationship betwixt Macular Vessel Density and Thickness and Central Visual Field successful Early Glaucoma,” was published successful Ophthalmology Glaucoma.
English (US)