Most-read Content of October: All-cause Excess Mortality, SGLT2 Inhibitors & Drug Safety Regulatory Response - Yale School of Medicine

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October 2022 Research Summary:

Uncoupling of all-cause excess mortality from COVID-19 cases successful a highly vaccinated state

An investigation published successful The Lancet Infectious Diseases indicated that successful Massachusetts, a authorities wherever astir 80% of its residents are afloat vaccinated, the astir caller question of SARS-CoV-2 corruption was not associated with an summation successful mortality.

Authors: Jeremy Samuel Faust, Benjamin Renton, Alexander Junxiang Chen, Chengan Du, Chenxue Liang, Shu-Xia Li, Zhenqiu Lin, Harlan M Krumholz


Characterization and corroboration of information signals identified from the US Food and Drug Administration Adverse Event Reporting System, 2008-19: transverse sectional study

In The BMJ.U.S. researchers analyzed information signals identified wrong the U.S. Food and Drug Administration (FDA) adverse lawsuit database.

Authors: Meera M Dhodapkar, Xiaoting Shi, Reshma Ramachandran, Evan M Chen, Joshua D Wallach, Joseph S Ross


SGLT2 Inhibitors Should Be Considered for All Patients With Heart Failure

Despite the emergence of evidence-based therapies for bosom nonaccomplishment with preserved ejection fraction, large entree and fiscal barriers remain. Read the editorial successful the Journal of the American College of Cardiology.

Authors: Tariq Ahmad, Nihar R. Desai, Eric J. Velazquez


The Prognostic Value of CAC Zero Among Individuals Presenting With Chest Pain

A systematic reappraisal and meta-analysis connected the lack of coronary artery calcium (CAC) arsenic a “gatekeeper” to place patients who would payment from precocious imaging thorax symptom valuation was featured successful JACC: Cardiovascular Imaging.

Authors: Ali M. Agha, Justin Pacor, Gowtham R. Grandhi, Reed Mszar, Safi U. Khan, Roosha Parikh, Tanushree Agrawal, Jeremy Burt, Ron Blankstein, Michael J. Blaha, Leslee J. Shaw, Mouaz H. Al-Mallah, Alexandria Brackett, Miguel Cainzos-Achirica, Edward J. Miller, Khurram Nasir


Prediction of Death oregon HF Hospitalization successful Patients With Severe FMR

In JACC: Cardiovascular Interventions, a probe squad utilized the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation) database to make a hazard prediction people for patients with terrible regurgitation oregon “leaky” valve.

Authors: Neeraj Shah, Mahesh V. Madhavan, William A. Gray, Sorin J. Brener, Yousif Ahmad, JoAnn Lindenfeld, William T. Abraham, Paul A. Grayburn, Saibal Kar, D. Scott Lim, Jacob M. Mishell, Brian K. Whisenant, Zixuan Zhang, Bjorn Redfors, Michael J. Mack, Gregg W. Stone

Submitted by Elisabeth Reitman connected October 12, 2022

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