ObesityWeek® 2022: What's Stopping Effective Treatment of Obesity? - Medscape

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ObesityWeek® 2022 is the largest planetary league connected obesity, with implicit 100 sessions, and coincides with the 40th day of the Obesity Society. Being held November 1-4, it is simply a hybrid gathering that participants tin be onsite, successful sunny San Diego, oregon virtually.

"The gathering offers a wide perspective, from basal science, each the mode to nationalist argumentation connected studies of attraction and prevention of obesity, " Program Planning Chair for ObesityWeek®, Kelly C. Allison, PhD, told Medscape Medical News successful an interview.

The Presidential Plenary league connected November 1 volition footwear disconnected the gathering with "a bid of 10-minute accelerated talks connected cutting-edge topics successful the field," noted Allison, who is besides director, Center for Weight and Eating Disorders, Hospital of the University of Pennsylvania, and prof of psychiatry, University of Pennsylvania, successful Philadelphia.

Among others, Ania M. Jastreboff, MD, PhD, volition talk astir "New developments successful anti-obesity pharmacotherapy," and Theodore K. Kyle, RPh, MBA, volition sermon "Reducing barriers to treatment: Insurance coverage."

"We're seeing immoderate beauteous effectual anti-obesity medication, but inactive they are not being covered by galore insurances," said Allison. Some clinicians mightiness beryllium hesitant to prescribe anti-obesity medications, remembering older drugs that were pulled from the marketplace for wellness concerns, and immoderate patients whitethorn besides person concerns, she speculated. There is simply a request for greater acquisition astir the existent anti-obesity drugs.

In his statesmanlike address, Dan Bessesen, MD, prof of medicine astatine the University of Colorado, volition sermon "Regulation of assemblage value and adaptive responses to value loss."

Pediatric obesity is simply a large absorption of this year's league too, Allison noted.

At 8 AM connected November 3, The Obesity Society, the World Obesity Federation, the European Association for the Study of Obesity, and Obesity Canada volition contiguous a associated symposium, "International innovations successful pediatric obesity," with speakers from Canada, Australia, and Ireland discussing ongoing paradigm shifts successful the prevention and attraction of pediatric obesity.

Two hours later, astatine a associated symposium by the American Academy of Pediatrics (AAP)/The Obesity Society, attendees volition get a behind-the-scenes look astatine the making of the caller AAP Obesity Clinical Practice Guideline for children and adolescents with obesity.

The league tracks bespeak the wide scope of this event: Track 1: Metabolism and Integrative Physiology; Track 2: Neuroscience; Track 3: Interventional and Clinical Studies; Track 4: Population Health; Track 5: Clinical/Professional Practice; Track 6: Policy/Public Health, and a subtrack: Eradicating Treatment Barriers.

Tirzepatide and More...

Allison highlighted the pursuing oral presentations and posters astir anti-obesity drugs:

  • "Once-weekly subcutaneous semaglutide 2.4 mg successful adolescents with overweight oregon obesity," with an extended Q&A session, November 2.

  • "Clinical outcomes with medicine usage successful tertiary pediatric value absorption program," by Enayet et al. Poster 030.

  • "The metabolically steadfast obese paradigm and liver abdominous contented successful the Fels longitudinal study," by Garza et al. Oral 055, November 2.

  • "Phase 3 objective proceedings of metformin for attraction of COVID-19 successful adults with overweight and obesity," by Bramante et al. Oral 067, November 3. This proceedings was published successful the New England Journal of Medicine, as reported previously. 

  • "Glucagon/GLP-1 receptor dual agonist BI 456906 reduces bodyweight successful patients with type 2 diabetes," by Rosenstock et al. Oral-063, November 3. 

  • "A randomized controlled proceedings of naltrexone and bupropion and behaviour therapy for binge-eating disorder," by Grilo et al. Oral 066, November 3.

And connected November 4, researchers volition contiguous 4 oral abstracts astir the dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide (Mounjaro), which is approved for benignant 2 diabetes and present has fast track designation for value nonaccomplishment from the US Food and Drug Administration. Oral abstracts 109, 110, 111, and 112 screen value nonaccomplishment with tirzepatide crossed antithetic property groups, assemblage wide indexes, and comorbidities, arsenic good arsenic prime of life.

Allison besides highlighted the pursuing presentations that screen different divers topics:

  • Family-based treatment: "Pilot survey to pass a randomized controlled proceedings of HeLP: Obesity prevention & attraction for the full Hispanic family," by Haemer et al. Oral 029. November 2.

  • Bariatric surgery: "Long-term outcomes of laparoscopic sleeve gastrectomy from 2010-2016: A nationwide cohort study," Oral 014. November 2.

  • Prevention/public health: "Impact of affirmative and antagonistic front-of-package nutrient labels successful a randomized experiment," by Grummon et al. Oral 068. November 3.

  • Time-restricted eating: "Effects of 8-hour clip restricted eating for value nonaccomplishment implicit 12 months," Gabel et al. Oral 102. November 4.

  • Patient management: "Identifying interprofessional drivers of signifier gaps successful the absorption of patients with obesity," by Robinson et al. Poster 055.

On November 4, researchers volition contiguous 5 winning papers that volition beryllium published successful the December contented of the Obesity journal about GLP-1 agonists versus bariatric surgery; monoacylglycerol O-acyltransferase 1 successful mice; a behavioral weight-loss intervention; the Canberra Obesity Management Service; and macronutrient (im)balance successful an obesogenic environment.

"I'm ever excited to perceive immoderate talks that are extracurricular of my comfortableness area to recognize the mechanisms of obesity better," concluded Allison.

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