Broadcast Date: November 15, 2022
Time: 11:00 americium PT, 02:00 p.m. ET, 20:00 CET
Comprehensive recognition of structural chromosomal aberrations is important successful objective work-up of hematological malignancy samples for close characterization, classification, and stratification of cases. With existent standard-of-care cytogenetic methods (Karyotyping, FISH, and CMA), galore abnormalities are missed owed to limitations of each approach, from debased solution to the inability to observe definite structural variant classes.
Optical Genome Mapping (OGM) has emerged arsenic a promising exertion that tin maximize the detection of each classes of chromosomal aberrations. Numerous technological studies person besides demonstrated that it not lone provides results that correlate to findings from accepted cytogenetics but besides reveals importantly much pathogenic variants of relevance, that unneurotic with mutational investigation by NGS, leads to amended characterization of samples and improvements successful prognosis hazard assessment.
This Inside Precision Medicine webinar is intended to supply the combined position of an oncologist, Dr. Garcia-Manero, and a pathologist, Dr. Kanagal-Shamanna, connected the inferior of Optical Genome Mapping successful Myelodysplastic Syndromes (MDS), a benignant of hematologic malignancy, based connected starring probe conducted by their groups astatine the MD Anderson Cancer Center.
Topics to beryllium addressed are the relation that cytogenetics and molecular genetics play successful MDS characterization, challenges faced by pathologists and oncologists erstwhile results are ambiguous oregon non-informative, and the expected interaction connected the objective probe field. In addition, results from precocious published data, and antithetic lawsuit studies, comparing OGM to different standard-of-care methods crossed a cohort of MDS samples volition beryllium discussed.
A unrecorded Q&A followed the presentation, offering a accidental to airs questions to our adept panelists.
English (US)