Credit: PacBioSequencing institution PacBio, and synthetic DNA institution Twist Bioscience announced contiguous the motorboat of a enactment of high-throughput long-read cistron panels. The archetypal offering of panels, sold nether the Twist Alliance name, are designed to seizure people regions of the genome, and besides connection customers the quality to customized plan panels based connected their circumstantial probe needs for sequencing with PacBio HiFi reads.
“Our customers person been asking for a mode to absorption their long-read experiments and maximize throughput,” said Christian Henry, president and CEO of PacBio. “Through this collaboration with Twist we person developed off-the-shelf products that we judge person delivered connected that capability. Collaborations similar this assistance america rapidly bring caller solutions to our customers and beforehand our ngo to alteration the committedness of genomics to amended quality health.”
The archetypal offering of the collaboration volition beryllium 2 panels: a 50-gene pharmacogenomics sheet and a sheet that includes astir 400 medically relevant, but challenging genes successful the alleged “dark” genome. Both PacBio and Twist worked with researchers are probe institutions to assistance place their needs and the absorption the caller Twist Alliance panels.
The larger sheet focuses connected medically relevant, hard to series regions of the genome and includes the SMN1 and SMN2, GBA, and LPA genes, which are known to beryllium associated with Spinal Muscular Atrophy, Alzheimer’s, and cardiovascular disease, respectively. The pharmacogenomics sheet focuses connected genes person shown precocious levels of grounds for usage successful prescribing medications.
“These panels developed with PacBio alteration customers to series regions of the genome that tin assistance researchers survey the relation of genetics successful cause effect and uncover regions that are hard to read, specified arsenic ‘dark genes’ and genes associated with neurodegenerative and cardiovascular diseases. Providing scientists with NGS tools enables them to further their probe and summation a amended knowing of the relation that definite genes play successful diseases, which could 1 time beryllium translated to breakthroughs for patients,” said Emily M. Leproust, PhD, CEO and co-founder of Twist Bioscience. “While these are long-read panels, Twist Alliance panels are developed successful concern with experts successful their tract to further probe and tin beryllium made to beryllium compatible with immoderate sequencing technology.”
While the existent merchandise focuses connected PacBio’s spot successful long-read sequencing, the companies besides announced that they are moving unneurotic to show the accuracy and capabilities of sequencing by binding (SBB) chemistry. The SBB exertion was acquired by PacBio successful its $800 cardinal acquisition of short-read sequencing institution Omniome. SBB has been touted for its debased mistake rates compared with existing short-read methods and promises to beryllium good suited for enactment successful oncology. In summation to its enactment with Twist, PacBio besides has an ongoing oncology collaboration with Invitae leveraging SBB.
As noted successful today’s property release: “By nature, SBB excels astatine correctly resolving homopolymer runs and repetitive regions. When applied to whole-exome sequencing, it has the imaginable to supply the astir implicit sum of some uncomplicated and traditionally hard to series genes which could streamline workflows by reducing the request for orthogonal assays.”
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