PET/MRI accurately predicts risk of prostate cancer recurrence after prostatectomy - Medical Xpress

In men precocious diagnosed with intermediate oregon high-grade prostate cancer, prostate circumstantial membrane antigen (PSMA), PET/MRI tin successfully find whether their crab is apt to instrumentality wrong 2 years of a prostatectomy. Armed with this information, physicians tin place patients who could payment from further attraction and/or predominant surveillance. This probe was published successful the December contented of the Journal of Nuclear Medicine.

Prostate crab is known to person precise adaptable behaviour and outcomes. While galore cases of localized prostate crab tin beryllium treated successfully, immoderate patients acquisition a accelerated progression adjacent aft prostatectomy oregon radiation therapy. Therefore, archetypal hazard stratification is important to find attraction decisions and consequent absorption of prostate crab patients.

"Clinicians presently usage biopsy findings and clinical information, specified arsenic prostate-specific antigen (PSA) levels, to foretell if prostate crab is slow-growing oregon if it volition dispersed rapidly and necessitate assertive treatments," said Andrei Iagaru, MD, prof of Radiology–Nuclear Medicine and main of the Division of Nuclear Medicine and Molecular Imaging astatine Stanford University Medical Center successful Stanford, California. "However, functional imaging, specified arsenic PET/MRI, is progressively being considered arsenic a mode to place patients astatine hazard for persistent oregon recurrent disease."

In the study, researchers examined the worth of ⁶⁸Ga-PSMA-11 PET/MRI for hazard stratification of recently diagnosed prostate patients anterior to archetypal therapy. Seventy-three patients with a caller diagnosis of intermediate- oregon high-grade prostate crab were imaged with ⁶⁸Ga-PSMA-11 PET/MR betwixt April 2016 and December 2020. PET findings were divided into groups based connected debased versus precocious uptake successful the superior lesion and the beingness oregon lack of metastatic disease. These findings were compared to biopsy results and objective information. The narration betwixt the PET/MRI findings and diligent outcomes were besides examined.

High uptake successful the superior lesion and the beingness of PSMA metastasis were associated with biochemical nonaccomplishment oregon accelerated recurrence wrong 2 years of prostatectomy. In contrast, patients with debased uptake successful the superior lesion who did not person grounds of metastatic illness connected PET/MRI had a debased likelihood of experiencing recurrence during the follow-up period.

"PSMA PET/MRI adds worth to the pre-therapy valuation of patients with recently diagnosed prostate cancer, and the accusation from PET seems to beryllium arsenic reliable, if not much reliable, than biopsy findings and objective accusation successful predicting which patients volition person suboptimal outcome," stated Farshad Moradi, MD, Ph.D., objective subordinate prof of Radiology–Nuclear Medicine astatine Stanford University Medical Center successful Stanford, California.

"This survey provides enactment for including PSMA PET to assistance successful objective determination making astir prostate cancer therapy options. PSMA pre-surgery whitethorn lend to establishing 1 of the 'killer applications' for PET/MRI."

Provided by Society of Nuclear Medicine and Molecular Imaging