Plant-based diet leads to greater reduction in advanced glycation end-products than diet with meat and dairy - Medical Xpress

Eating a plant-based fare reduces inflammatory dietary precocious glycation end-products (AGEs) by 79%, compared to a 15% simplification for a fare that includes nutrient and dairy products, according to a caller survey by researchers with the Physicians Committee for Responsible Medicine published successful Obesity Science & Practice. The alteration successful AGEs was associated with an mean value nonaccomplishment of 14 pounds and improved insulin sensitivity.

"Simply swapping fatty nutrient and dairy products for a low-fat plant-based diet led to a important alteration successful precocious glycation end-products—inflammatory compounds recovered to a greater grade successful animal products than plants," says pb survey writer Hana Kahleova, MD, Ph.D., manager of objective probe astatine the Physicians Committee for Responsible Medicine. "The alteration successful AGEs was besides associated with value nonaccomplishment and improved insulin sensitivity."

AGEs are compounds that are formed successful the bloodstream erstwhile proteins oregon fats harvester with glucose. AGEs origin inflammation and oxidative stress, which yet pb to chronic diseases, including benignant 2 diabetes and cardiovascular disease.

AGEs whitethorn beryllium ingested done the diet, and carnal products are mostly higher successful AGEs than works foods. AGEs are besides formed during mean metabolism but are formed astatine an accrued complaint erstwhile a idiosyncratic has metabolic syndrome—high humor sugar, precocious cholesterol, precocious humor pressure, and insulin resistance.

In the study, 244 participants who were overweight were randomly assigned to an intervention group, which ate a low-fat plant-based diet, oregon power group, which made nary dietary changes, for 16 weeks.

At the opening and extremity of the study, assemblage creation was measured and insulin sensitivity was assessed. Dietary AGEs were calculated based connected self-reported dietary intake records. A dietary AGEs database was utilized to estimation dietary AGEs intake.

Dietary AGEs decreased by 79% successful the plant-based group, compared to 15% successful the power group. About 55% of the simplification of the dietary AGEs successful the plant-based radical was attributable to the simplification successful nutrient intake, 26% to decreased dairy intake, and 15% to decreased depletion of added fats. The simplification successful achromatic nutrient depletion made the biggest quality successful dietary AGEs coming from nutrient (59%), followed by processed nutrient (27%).

Body value decreased by astir 14 pounds (6.4 kg) successful the plant-based group, compared with astir 1 lb (0.5 kg) successful the control group, mostly owed to a simplification successful abdominous mass, notably visceral fat. Insulin sensitivity improved successful the involution group.

The authors accidental that these findings enactment anterior observations of the favorable effects of low-AGEs diets connected weight, assemblage fat, and insulin resistance.

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More information: Hana Kahleova et al, Dietary precocious glycation products and their associations with insulin sensitivity and assemblage weight: A 16‐week randomized objective trial, Obesity Science & Practice (2022). DOI: 10.1002/osp4.646

Provided by Physicians Committee for Responsible Medicine