Reflex medical device app used for studies on opiate withdrawal, military concussions - Purdue University

Tool from high-tech institution Brightlamp is being utilized successful objective studies funded by the NIH and DOD

WEST LAFAYETTE, Ind. – Third-party probe groups and organizations person validated a smartphone app called Reflex arsenic a instrumentality to assistance diagnose aesculapian conditions similar concussions and opiate withdrawal.

Brightlamp CEO Kurtis Sluss said Reflex has been utilized astatine implicit 200 clinics, with much than 90,000 tests administered to date. More than 30,000 patients person benefited from Reflex’s accelerated neurological assessment. Brightlamp has commercialized the app.

Reflex is an autonomic vitals appraisal instrumentality rooted successful pupillometry, the measurement of however overmuch and however accelerated the eye’s pupil size changes successful effect to a stimulus. The instrumentality takes a integer video signaling of the oculus to measurement a effect called the pupillary airy reflex. The idiosyncratic holds the camera up to the oculus and taps the smartphone screen, and a airy flashes to initiate a effect from the pupil. Reflex is simply a Class I 510(k) exempt regulated aesculapian device, according to the U.S. Food and Drug Administration.

Sluss said OpiAID, a information subject company, independently determined that Reflex is simply a predictor of opiate withdrawal, which could beryllium utilized to combat the opioid epidemic successful the U.S.

“As portion of a survey funded by the National Institutes of Health, objective researchers rigorously evaluated Reflex to find its efficacy arsenic a stand-alone and a operation appraisal addressing opiate addiction,” Sluss said. “Reflex volition assistance interventionists successful the opioid epidemic retrieve fast, reliable and close information. Now, addiction betterment specialists tin entree this cognitive biomarker to amended recognize and optimize addiction recovery.”

Christopher Evonko, the OpiAID probe survey coordinator and a doctoral campaigner successful the University of North Carolina Wilmington’s Department of Psychology, said pupillometry measures obtained from Reflex outperformed modular self-report and observational measures during a survey to measure the appraisal of opioid withdrawal. Evonko said the metric was importantly associated with the clip elapsed since a patient’s past opioid dose.

“Accurate and reliable quantification of opioid withdrawal is of captious value to guiding dosing decisions successful the proviso of medically assisted treatments of opioid usage disorder,” Evonko said. “The Reflex app addresses the accessibility interest of accepted pupillometry instrumentality and has the imaginable to positively interaction the opioid pandemic by providing clinicians with actionable information to amended diligent retention and, ultimately, attraction outcomes.”

Sluss said objective findings person besides shown that Reflex was utile successful diagnosing concussions arsenic portion of a 2021 published study, with independent, validating probe being presented successful 2022. 

“This has driven aesculapian researchers astatine the University of Maryland, successful concern with the U.S. Department of Defense, to usage Reflex successful a two-year objective proceedings to measure 1,200 soldiers experiencing encephalon injury,” Sluss said.

“Reflex was called retired by University of Maryland researchers arsenic the highest-scoring concussion objective decision-support instrumentality among galore different salient concussion tools connected the market. This preliminary valuation indicates however almighty Reflex tin beryllium successful a subject setting.”

Sluss said different third-party studies are ongoing, opening an array of opportunities for Reflex users.

“Our extremity is to go the modular instrumentality successful screening cognitive health, careless of ailment,” Sluss said. “These parallel studies are showing affirmative results and proving what we already knew: The eyes are a captious entree constituent to managing brain-related wounded and disease.”

Brightlamp has opened up concern successful its institution done StartEngine, a regulated crowdfunding organization, to enactment Reflex’s adjacent question of developments and marketplace advancements. The run tin beryllium recovered online astatine http://www.startengine.com/reflex.

Brightlamp’s program for Reflex is to proceed elevating information mentation for objective determination enactment based connected autarkic information published by Reflex users.

“We person built an fantabulous Reflex community, and we’re collectively excited astir however utile this easy-to-use aesculapian app is shaping up to be,” Sluss said.

Sluss has received commercialization guidance from the Purdue Foundry, an entrepreneurship and commercialization hub housed successful the Convergence Center for Innovation and Collaboration successful Discovery Park District astatine Purdue, located adjacent to the Purdue University campus. His institution is present portion of the Purdue Foundry's Double Down Experiment, which includes high-growth businesses.

About Brightlamp

Brightlamp is an Indiana-based wellness attraction exertion institution that specializes successful frontier machine imaginativeness methods. As recognized by experts, specified arsenic Donald Kuratko of Indiana University, the institution develops innovative neurological breakthrough methods and applies them to mobile solutions to assistance successful the advancement of cognitive wellness care.

Brightlamp's premier patented exertion monitors the eye's absorption to airy truthful aesculapian professionals tin get much close and accordant neurological accusation successful seconds done a mobile device. The sanction iPhone and iPad are registered trademarks of Apple Inc. For much information, sojourn https://reflexapp.io/. 

About Purdue Foundry

The Purdue Foundry is an entrepreneurship and commercialization hub whose professionals assistance Purdue innovators make startups. The Purdue Foundry is managed by the Purdue Research Foundation, which received the 2019 Innovation and Economic Prosperity Universities Award for Place from the Association of Public and Land-grant Universities. Contact the Purdue Foundry astatine foundry@prf.org.

Writer/Media contact: Steve Martin, sgmartin@prf.org

Sources: Kurtis Sluss, ksluss@brightlamp.org

Christopher Evonko, cje9786@uncw.edu