Scientists Identify New Potential Benefits of Statins Beyond Lowering Cholesterol - SciTechDaily

Recent probe links the cholesterol-lowering drugs to a little hazard of bleeding stroke. 

According to caller probe individuals who usage statins, a people of drugs that alteration cholesterin levels whitethorn person a decreased hazard of an intracerebral hemorrhage. Intracerebral hemorrhage is simply a benignant of changeable caused by bleeding successful the brain. The survey was precocious published successful the diary Neurology.

“While statins person been shown to trim the hazard of changeable from humor clots, determination has been conflicting probe connected whether statin usage increases oregon decreases the hazard of a idiosyncratic having a archetypal intracerebral hemorrhage,” said survey writer David Gaist, MD, Ph.D., of the University of Southern Denmark successful Odense and a subordinate of the American Academy of Neurology. “For our study, we looked astatine the lobe and non-lobe areas of the encephalon to spot if the determination was a origin for statin usage and the hazard of a archetypal intracerebral hemorrhage. We recovered that those who utilized a statin had a little hazard of this benignant of bleeding changeable successful some areas of the brain. The hazard was adjacent little with semipermanent statin use.”

The lobe country of the encephalon includes astir of the cerebrum, including the frontal, parietal, temporal, and occipital lobes. The non-lobe country chiefly includes the basal ganglia, thalamus, cerebellum, and brainstem.

For the study, researchers looked astatine wellness records successful Denmark and identified 989 radical with an mean property of 76 who had an intracerebral hemorrhage successful the lobe country of the brain. They were compared to 39,500 radical who did not person this benignant of changeable and were akin successful age, sex, and different factors.

They besides looked astatine 1,175 radical with an mean property of 75 who had an intracerebral hemorrhage successful the non-lobe parts of the brain. They were compared to 46,755 radical who did not person this benignant of changeable and were akin successful age, sex, and different factors.

Researchers utilized medicine information to find accusation connected statin use.

Of the full participants, 6.8% who had a changeable had been taking statins for 5 oregon much years, compared to 8.6% of those who did not person a stroke.

After adjusting for factors similar precocious humor pressure, diabetes, and intoxicant use, researchers recovered that radical presently utilizing statins had a 17% little hazard of having a changeable successful the lobe areas of the encephalon and a 16% little hazard of changeable successful the non-lobe areas of the brain.

Longer usage of statins was associated with a little hazard of changeable successful some areas of the brain. When utilizing statins for much than 5 years, radical had a 33% little hazard of having a changeable successful the lobe country of the encephalon and a 38% little hazard of changeable successful the non-lobe country of the brain.

“It’s reassuring quality for radical taking statins that these medications look to trim the hazard of bleeding changeable arsenic good arsenic the hazard of changeable from humor clots,” Gaist added. “However, our probe was done successful lone the Danish population, which is chiefly radical of European ancestry. More probe should beryllium conducted successful different populations.”

Reference: “Association Between Statin Use and Intracerebral Hemorrhage Location: A Nested Case-Control Registry Study” by Nils Jensen Boe, Stine Munk Hald, Mie Micheelsen Jensen, Jonas Asgaard Bojsen, Mohammad Talal Elhakim, Sandra Florisson, Alisa Saleh, Anne Clausen, Sören Möller, Frederik Severin Gråe Harbo, Ole Graumann, Jesper Hallas, Luis Alberto García Rodríguez, Rustam Al-Shahi Salman, Larry B. Goldstein and David Gaist, 7 December 2022, Neurology.
DOI: 10.1212/WNL.0000000000201664

The survey was funded by the Novo Nordisk Foundation.