Several Yale Program in Addiction Medicine Faculty Members Receive New NIH HEAL Initiative Awards - Yale School of Medicine

The National Institutes of Health describes the Helping End Addiction Long-term (HEAL) Initiative arsenic “an aggressive, trans-agency effort to velocity technological solutions to stem the nationalist opioid nationalist wellness crisis.” Initiated successful 2018, the 2.5 cardinal dollar inaugural funds much than 1,000 projects crossed the state to beforehand knowing and attraction of opioid, different substance usage disorders and pain. Among caller awardees are respective halfway module members successful the Yale Program successful Addiction Medicine. Projects include:

HEAL Data2Action Research Adoption Support Center

This project, helmed by mPIs Dr. Mark McGovern, PhD, Sara Becker, PhD, William Becker, MD, and C. Hendricks Brown, PhD, volition found the HEAL Data2Action Research Adoption Support Center. This Center volition execute respective functions, among them supporting HEAL Data2Action Innovation Projects. This enactment volition travel successful the signifier of on-demand method assistance, facilitation of a learning collaborative, proviso of implementation support, and assistance with spouse engagement. In addition, the Center volition enactment gathering of grounds for prevention and attraction practices, improvement and valuation of implementation strategies, feedback postulation and scalability assessment. Dr. Becker volition service arsenic Director of the Pain Implementation Support Core wrong the Center, and David Fiellin, MD, volition beryllium among halfway module successful the Substance Use Disorder Implementation Support Core.

Using System Dynamics Modeling to Foster Real-Time Connections to Care

First responders forestall galore overdose deaths by providing life-saving resuscitation and giving naloxone to reverse an opioid overdose. Using a modeling approach, Rebekah Heckmann, MD, MPH, MPA, Nasim Sabounchi, PhD, and squad volition measure the interaction of Good Samaritan Laws, intended to support radical from definite transgression penalties if calling 911 to respond to an overdose, connected overdose mortality. Heckmann and squad volition make and trial a telehealth level to beryllium utilized astatine the clip of an opioid overdose to link patients with entree to medicine for opioid usage disorder, harm simplification services, and betterment support.

National Institute connected Drug Abuse Clinical Trial Network: New England Consortium Node - Supplement to Address Opioid Use Disorder Treatment Disparities Among Black and Latino Individuals

In supplement to ongoing HEAL-funded probe successful the NIDA Clinical Trial Network (CTN) New England Consortium Node (mPI Gail D'Onofrio, MD, MS), a caller task led by Edouard Coupet II, MD, MS and Dr. D'Onofrio volition question to elicit imaginable targets for exigency department-based interventions to amended engagement successful addiction attraction among Black and Latino individuals with untreated opioid usage disorder. To execute this, Dr. Coupet and squad volition behaviour semi-structured interviews of Black, Latino, and non-Latino White participants arsenic good arsenic as supplemental analyses of antecedently identified predictors of worse attraction outcomes. Findings volition pass improvement of an ED-based involution to heighten attraction engagement wrong this population, consequent to an ED visit.

A Longitudinal Qualitative Study of Fentanyl-Stimulant Polysubstance Use Among People Experiencing Homelessness

Individuals experiencing homelessness are much apt to usage some fentanyl and stimulants and acquisition drug-related harms arsenic compared to stably housed counterparts. mPIs Ryan McNeil, PhD, and Kelly R. Knight, PhD, volition analyse fentanyl-stimulant polysubstance usage patterns successful narration to lodging status. McNeil, Knight, Kimberly Sue, MD, PhD, and colleagues volition additionally analyse usage of overdose prevention and substance usage upset attraction interventions successful stateless individuals who usage some fentanyl and stimulants, including however polysubstance usage patterns signifier hazard of overdose implicit time.

Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR-YOU) Research Center Supplement to Study Transmucosal Buprenorphine and Oral Infections

The Food and Drug Administration precocious issued a informing concerning the usage of transmucosal buprenorphine and adverse dental outcomes. There is simply a important spread successful knowing of this issue. With a supplement to ongoing activities of the IMPOWR-YOU Research Center (mPIs William Becker, MD, Declan Barry, PhD, and David Fiellin, MD) and gathering connected anterior enactment to measure the interaction of prescribed opioids connected infectious outcomes, Becker, E. Jennifer Edelman, MD, MHS, Kirsha Gordon, PhD, and colleagues volition utilize Veterans Health Administration information to analyse the relation betwixt semipermanent opioid agonist (full oregon partial) receipt and bony decay, cavities, oral infections, and nonaccomplishment of teeth.

Prior Yale Program successful Addiction Medicine affiliated HEAL awards include:

• The Role of Family Functioning successful Race/Ethnicity connected the Efficacy of an Opioid Misuse Prevention Videogame Intervention for Adolescents (Lynn E. Fiellin, MD; Uche Aneni, MD, MHS)
• HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (William Becker, MD; Declan Barry, PhD; David Fiellin, MD)
• Transitions Clinic Network: Post Incarceration Addiction Treatment, Healthcare, andSocial Support (TCH PATHS) Study (Emily A. Wang, MD, MA)
• Gaunfacine Target Engagement and Validation to Improve Substance Use Outcomes successful Women (Rajita Sinha, PhD)
• A Digital Intervention to Prevent the Initiation of Opioid Misuse successful Adolescents successful School-Based Health Centers (Lynn E. Fiellin, MD)
• Video-Telecare Collaborative Pain Management to Improve Function and Reduce Opioid Risk successful Patients with End Stage Renal Disease Receiving Hemodialysis (William Becker, MD; Susan T. Crowley, MD; Denise Esserman, MD; Alicia Heapy, PhD)
• The Collaboration Linking Opioid Use Disorder and Sleep (CLOUDS) Study (Henry Klar Yaggi, MD, PhD; Nancy S. Redeker, RN, PhD, FAHA, FAAN); Dustin Scheinost, PhD; Declan Barry, PhD)
• Pain Management Collaboratory Coordinating Center (Robert D. Kerns, PhD; Cynthia. A Brandt, MD, MPH)
• Long-acting Buprenophine vs. Naltrexone Opioid Treatments successful CJS-Involved Adults (Joshua D. Lee, MD, MSc; David J. Farabee, PhD; Lisa A. Marsch, PhD; Robert P. Schwartz, MD; Sandra A. Springer, MD; Elizabeth N. Waddell, PhD)

Language presented successful this nonfiction is adapted from the NIH HEAL Initiative Funded Projects website.