Small study links prior SARS-CoV-2 infection with coronary vasomotor dysfunction - Healio

Prior SARS-CoV-2 corruption was associated with coronary vasomotor dysfunction, careless of whether the diligent required hospitalization, according to a little connection published successful the Journal of the American Heart Association.

“When compared with a matched power radical without anterior COVID-19 wrong a akin clip frame, patients with anterior COVID-19 had greater frequence and severity of coronary vasomotor dysfunction with little maximal myocardial humor travel and myocardial humor travel reserve, a concordance that reflects the highest objective risk,” Brittany Weber, MD, PhD, cardiologist astatine Brigham and Women’s Hospital and teacher successful medicine astatine Harvard Medical School, and colleagues wrote. “SARS-CoV-2 corruption has been shown to beryllium associated with endothelial dysfunction, and these results whitethorn suggest an acceleration of endothelial dysfunction oregon adjacent a progression of atherosclerosis that occurs successful the setting of SARS-CoV-2 infection.”

Data were derived from Weber B, et al. J Am Heart Assoc. 2022;doi:10.1161/JAHA.122.025844.

For this study, researchers astatine Brigham and Women’s Hospital identified 34 patients with confirmed SARS-CoV-2 corruption who underwent myocardial accent perfusion PET from April 2020 to July 2021 (median clip to imaging, 4.6 months). Measures of myocardial perfusion and humor travel reserve were compared with 103 matched controls without anterior SARS-CoV-2 corruption who underwent myocardial accent perfusion PET during the aforesaid period.

The superior result was prevalence of coronary vasomotor dysfunction, defined arsenic myocardial humor travel reserve little than 2 associated with a maximal myocardial humor travel of little than 1.8 mL/min/g.

CV hazard factors specified arsenic obesity (67.7%), hypertension (91.2%), hyperlipidemia (91.2%) and diabetes (55.8%) were communal among patients with confirmed SARS-CoV-2 infection.

Fifty-three percent of patients with COVID-19 had abnormal myocardial perfusion connected N13- ammonia PET.

Researchers observed myocardial humor travel reserve little than 2 successful 44% of the patients with confirmed SARS-CoV-2 corruption compared with 11.7% of matched controls (P < .001). The quality remained important erstwhile the investigation was restricted to patients with visually mean PET scans (P < .001). The researchers posited that these findings are not lone related to epicardial CAD but whitethorn bespeak an abnormal microcirculatory effect to stress.

In addition, mean myocardial humor travel reserve was 19.4% little successful patients with confirmed SARS-CoV-2 corruption compared with the power radical (2 vs. 2.48; P < .001).

There was nary quality successful mean myocardial humor travel reserve among patients with confirmed SARS-CoV-2 corruption requiring hospitalization compared with those who did not necessitate hospitalization (P = .5).

“In survivors, the longer-term cardiovascular consequences of COVID-19 are chartless and important to delineate to pass therapeutic strategies for semipermanent sequelae beyond acute illness, including the hazard of myocardial infarction and changeable from endothelial damage,” the researchers wrote. “The excess microvascular hazard successful this survey supports a imaginable relation for vascular endothelial harm and/or inflammation successful driving coronary vasomotor abnormalities that mightiness lend to excess cardiovascular hazard successful this population.”