The survey covered successful this summary was published successful medRxiv as a preprint and has not yet been adjacent reviewed.
Key Takeaway
Older men who fume whitethorn beryllium much apt to make metastatic and fatal prostate cancer.
Why This Matters
In astir cases, prostate crab hazard is determined by unmodifiable, inherited traits; however, this survey suggests that manner factors — smoking, successful peculiar — tin besides contribute. A steadfast manner whitethorn curb the hazard of prostate crab mortality successful high-risk men.
Study Design
Researchers gathered information from the Department of Veteran Affairs Million Veteran Program, a population-based survey with genotyping, semipermanent follow-up, and linked objective records for implicit 870,000 participating US veterans.
Overall, 281,923 patients participated (median age, 68 years astatine enrollment). They completed a questionnaire with astir 400 in-depth questions connected manner factors, including smoking, assemblage wide scale (BMI), and exercise.
The survey accounted for race/ethnicity, household history, and familial risk.
Key Results
Not smoking was independently associated with little hazard of metastatic prostate cancer (hazard ratio [HR], 0.54).
Nonsmokers were besides astatine a ower hazard of fatal prostate crab (HR, 0.35).
Higher BMI was independently associated with a somewhat little hazard of fatal prostate crab (HR, 0.97)
Exercise was associated with little hazard of metastatic illness (HR, 0.74) and fatal illness (HR, 0.74); however, workout was not independently associated with prostate crab endpoints connected multivariable analysis.
Limitations
Diet was not included successful the multivariable analysis.
Lifestyle factors were lone measured astatine the clip of enrollment successful the program, and fluctuations implicit clip were not captured.
Disclosures
The survey received backing from the Veterans Health Administration, the National Institutes of Health, the National Institute of Aging, the National Institute of Biomedical Imaging and Bioengineering, the Prostate Cancer Foundation, the University of California, the Marxuach Family Fellowship, and the Moores Cancer Center, University of California Health.
This is simply a summary of a preprint probe study, "Healthy Lifestyle and Prostate Cancer Risk successful the Million Veteran Program." The survey has not been adjacent reviewed. The afloat substance tin beryllium recovered astatine medRxiv.
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