A determination enactment strategy called GI TARGET whitethorn assistance integrate precision medicine into regular attraction for patients with gastrointestinal cancer, according to probe published successful JCO Precision Oncology.
GI TARGET offers oncologists “expert-led guidance connected the mentation and implementation” of tumor molecular profiling results, according to researchers.
In investigating GI TARGET, the researchers recovered it was some scalable and sustainable. However, astir of the oncologists studied did not travel GI TARGET recommendations.
The GI TARGET strategy progressive a multidisciplinary squad reviewing tumor molecular profiling results for patients with gastrointestinal cancers. Based connected these results, the squad recommended attraction oregon absorption strategies for these patients.
The squad identified due objective trials utilizing the computational matching level MatchMiner, suggested targeted therapy options (on- oregon off-label), oregon recommended further testing.
The researchers tested the GI TARGET strategy utilizing genomic information from 542 patients with gastrointestinal cancers who underwent tumor molecular profiling with OncoPanel oregon different tests successful the archetypal 6 months of 2019.
The squad provided summary reports of recommendations for 93% of patients (n=506). The patients had colorectal crab (39%), pancreatic crab (24%), esophagogastric crab (13%), biliary tract crab (8%), gastrointestinal neuroendocrine tumors (8%), and cancers of chartless superior (5%).
The reports were fixed to the 19 aesculapian oncologists treating these patients. The reports recommended 1 oregon much precision medicine objective trials for 80% of patients, and this led to 24 patients enrolling connected trials.
The reports besides recommended on-label targeted therapies for 6% of patients and off-label targeted therapies for 25%. Recommendations for further oregon orthogonal molecular investigating were made for 42% of patients.
Clinical information from the patients’ physics wellness records were collected from June to November 2020 to measure the superior oncologists’ enactment connected the ground of these recommendations.
The superior oncologists followed the recommendations for 16% of patients who had follow-up data. The researchers acknowledged that this effect was modest, but they noted that “this fig should beryllium interpreted successful the discourse of abbreviated follow-up and cosmopolitan reappraisal of cases since the trigger for GI TARGET reappraisal is the merchandise of OncoPanel results arsenic opposed to a alteration successful objective presumption oregon supplier request.”
“Our programme adds worth to OncoPanel and different tumor profiling done computationally driven objective proceedings matching, multidisciplinary reappraisal of tumor genomics, and prioritization of therapeutic options,” the researchers concluded.
Disclosures: Some survey authors declared affiliations with biotech, pharmaceutical, and/or instrumentality companies. Please spot the archetypal notation for a afloat database of disclosures.
Reference
Keller RB, Mazor T, Sholl L, et al. Programmatic precision oncology determination enactment for patients with gastrointestinal cancer.JCO Precis Oncol. Published online January 12, 2023. doi:10.1200/PO.22.00342
English (US)