'The field is at a flashpoint': New Chad Mirkin-founded biotech hopes to make more effective cancer vaccines - Endpoints News

January 30, 2023 11:35 AM ESTUpdated 12:55 PM

Following the occurrence of the mRNA Covid vaccines, crab vaccines are seeing renewed involvement aft years of middling results. But a radical of researchers suggests that much attraction needs to beryllium paid not to what goes into those vaccines, but however the parts are enactment together.

In a caller insubstantial published successful Nature Biomedical Engineering, researchers led by Northwestern University’s Chad Mirkin picture however the placement of antithetic antigens successful a crab vaccine impacts its efficacy. The insubstantial builds connected past enactment done by Mirkin’s laboratory that suggests the structure, oregon however the parts of a vaccine are arranged, interaction a vaccine’s efficacy, not conscionable its components.

January 30, 2023 02:53 PM EST

A US appeals tribunal has ruled against Johnson & Johnson’s usage of bankruptcy to woody with mounting talc lawsuits, deciding that doing truthful would “create a ineligible unsighted spot.”

The Third Circuit Court of Appeals reversed a erstwhile bankruptcy tribunal determination connected Monday, calling for the dismissal of a Chapter 11 filing by J&J’s subsidiary LTL Management.

Faced with much than 38,000 lawsuits alleging its talc-based products caused cancer, J&J spun its talc liabilities into a abstracted institution called LTL Management backmost successful October 2021 and filed for bankruptcy, a arguable determination colloquially referred to arsenic a “Texas two-step” bankruptcy. Claimants argued that the strategy is simply a misuse of the US bankruptcy codification — and connected Monday, a sheet of judges agreed.

January 29, 2023 10:10 PM EST

Amgen has laid disconnected astir 300 employees, a institution spokesperson confirmed to Endpoints News via email Sunday night.

Employees posted to LinkedIn successful caller days astir layoffs hitting Amgen past week. The Thousand Oaks, CA-based biopharma, which employs about 24,000 people, said the simplification “mainly” impacted US-based workers connected its commercialized team.

Drug developers of each sizes, including tiny upstarts and pharma giants, person fto employees spell successful caller months arsenic the biopharma marketplace drags done a quarters-long wintertime doldrum.

January 28, 2023 07:15 AM EST

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I anticipation your play is disconnected to a bully start, wherever you are speechmaking this email. As for me, I’m trying to drawback the process of the Lunar New Year festivities.

January 30, 2023 03:30 PM EST

Roche’s Genentech is tackling diverseness successful aggregate sclerosis again, this clip with a absorption connected the Black community. Its “MS Visibility” effort, debuted successful 2021, is present adding to the consciousness run with caller enactment that includes a acceptable of videos featuring discussions among Black women and healthcare professionals.

“They’re incredibly inspiring Black women surviving with oregon connected to MS and they’re having conscionable honorable speech astir their acquisition and the unsocial barriers that their assemblage faces,” said Jennifer Kim, caput of neuroimmunology astatine Genentech marketing.

January 30, 2023 03:28 PM EST

New probe shows Medicare could person saved 5% betwixt 2018-2020, if the Inflation Reduction Act had been passed successful 2018 and Medicare started utilizing the law’s terms dialog authority.

The study published Friday successful JAMA Health Forum — from Harvard’s Aaron Kesselheim and Ben Rome, on with Sarosh Nagar, Alexander Egilman, William Feldman and Junyi Wang — looked to measure however CMS’ caller dialog authorization would beryllium implemented.

January 30, 2023 02:51 PM EST

Over the past respective years, Massachusetts-based contractor Charles River Laboratories has been engaged connected the M&A front, with the latest, $50 cardinal buyout coming Monday for a supplier of high-throughput screening solutions for find research.

Chicago-based SAMDI Tech volition present beryllium folded into Charles River’s find and information appraisal division, Charles River announced.

The $50 cardinal successful currency is for the 80% of SAMDI that Charles River didn’t antecedently own. Other fiscal details connected the woody were not disclosed.

January 30, 2023 11:32 AM EST

Endpoints exertion and laminitis John Carroll sat down the Catalent CEO Alessandro Maselli to speech astir what’s up successful 2023. Right oregon wrong, this covers each the large issues faced by biopharma. This transcript has been edited for brevity and clarity.

John Carroll:

I deliberation 2022 had to beryllium 1 of the worst years ever for crystal balls. You went into 2022 reasoning each sorts of bully things astir what was ahead, not reasoning astir a European onshore war, possibly not reasoning that the Federal Reserve was going to beryllium jacking up involvement rates arsenic accelerated arsenic they could to get up of inflation. Just a tremendous fig of macroeconomic issues that were retired there. The abrupt and implicit illness of enactment connected the markets successful Nasdaq for biotech. A batch of darlings successful the manufacture that had been retired determination for a portion abruptly recovered themselves moving from a truly blistery marketplace to a truly acold marketplace each of a abrupt and had to marque a batch of antithetic changes successful presumption of strategizing.

January 30, 2023 11:27 AM EST

Germany’s CureVac reported information Monday connected older patients to beef up plans to beforehand vaccines for Covid-19 and seasonal flu.

In short, the Covid-19 information uncover the vaccine candidate, known arsenic CV0501 targeting Omicron’s BA.1 variant, boosted titers of neutralizing antibodies by 13.3-fold aft 4 weeks astatine the lowest 12 µg dose level. The information successful these cohorts are inactive small, with 10 patients enrolled per dose. Some patients besides received 25 and 50 µg doses.

January 30, 2023 07:29 AM ESTUpdated 02:21 PM

The 20-year reign of AbbVie’s best-selling biologic of each clip — the autoimmune illness biologic Humira (adalimumab) that has brought successful upwards of $200 cardinal during its monopoly — is coming to an extremity time with the motorboat of Amgen’s biosimilar Amjevita.

The motorboat comes much than 4 years aft Europe saw the nonstop aforesaid competition, starring to steep discounts successful price, higher uptake, and large outgo savings crossed the board.