The study covered successful this summary was published connected ResearchSquare.com arsenic a preprint and has not yet been adjacent reviewed.
Key Takeaway
All-cause mortality complaint successful the precocious visceral abdominous country (VFA) radical was importantly higher than successful the debased VFA group.
Why This Matters
Assessing VFA astatine baseline is meaningful to hazard stratification and prognostic appraisal successful patients with heart failure with preserved ejection fraction (HFpEF).
Study Design
This was a prospective cohort survey of patients with HFpEF recruited from the First Affiliated Hospital of Chongqing Medical University from September 2020 to January 2022.
A full of 297 inpatients diagnosed with HFpEF were considered for this study. Patients with terrible liver insufficiency (elevated liver enzymes: 3 times implicit precocious notation bounds oregon liver cirrhosis), terrible kidney insufficiency (eGFR <30 mL/min/1.73m2), past of autoimmune disease, crab diagnosis astatine the opening of the study, oregon near ventricular ejection fraction little than 50% astatine immoderate clip were excluded from this study.
The superior result was all-cause mortality.
VFA was measured done the multifrequency bioelectrical impedance analyzer.
The thickness of epicardial adipose insubstantial (EAT) and pericardial adipose insubstantial (PAT) was measured by echocardiography.
Key Results
A full of 172 patients with an mean property of 72 years were analyzed, of which 59.9% were female, 66% had hypertension, and 40% had atrial fibrillation.
Patients were divided into the debased VFA radical (VFA <148.3 cm2) oregon precocious VFA radical (VFA ≥148.3 cm2) based connected the optimal prognostic cutoff.
The median follow-up was 13 months (395.5 days) (interquartile range: 207.5 - 535.5 days), during which 7 patients died.
The all-cause mortality complaint successful the precocious VFA radical was importantly higher than successful the debased VFA radical (6 deaths vs 1 death; log-rank P < .0001).
Patients with higher VFA were older, had higher assemblage wide scale (BMI), and higher rates of preexisting hypertension and atrial fibrillation.
Age, smoking, BMI, H2PEFF score, and VFA were importantly associated with higher mortality successful HFpEF, whereas PAT thickness, EAT thickness, waist/hip ratio, assemblage abdominous mass, and abdominal obesity were not.
In the afloat adjusted model, VFA remained importantly associated with all-cause mortality (hazard ratio, 1.048; 95% CI, 1.005 - 1.092; P = .026).
Limitations
This was a single-center, tiny illustration size study.
Rigorous regression investigation was unattainable owed to the tiny fig of events.
Results of the investigation whitethorn person bias not identified and resolved.
Only patients with signs oregon symptoms of bosom nonaccomplishment were included, which whitethorn person excluded immoderate asymptomatic individuals oregon individuals falsely diagnosed with HFpEF arsenic a effect of dyspnea that was not owing to cardiac origin.
Disclosures
This enactment was supported by the National Natural Science Foundation of China; Chongqing Science and Technology Joint Project 2021; Basic Science and Foreword Technology Research Project; Chongqing Returnees Stay and Create Fund 2020, Chongqing High-end Talent Fund; China Cardiovascular Health Alliance-Access Research Fund; and the Chongqing Science and Health Union Medical Research Project.
The authors state nary conflicts of interest.
This is simply a summary of a preprint probe study, "Visceral adiposity : A imaginable marker for mortality hazard successful bosom nonaccomplishment with preserved ejection fraction?" written by Jin Zhao, from The First Affiliated Hospital of Chongqing Medical University, and colleagues connected ResearchSquare, provided to you by Medscape. This survey has not yet been adjacent reviewed. The afloat substance of the survey tin beryllium recovered connected ResearchSquare.com.
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