1. In this multi-center randomized controlled trial, vitamin C supplementation successful large smokers was associated with amended lung relation successful offspring astatine the property of five.
2. Additionally, vitamin C supplementation successful large smokers was besides associated with decreased occurrence of wheezing successful offspring.
Evidence Rating Level: 1 (Excellent)
Exposure to cigaret smoking in utero is simply a hazard origin for impaired fetal lung development, decreased airway function, and improvement of asthma successful the offspring. Supplementation of vitamin C for large smokers has been shown to summation offspring airway relation until the property of 12 months. However, the semipermanent effects of vitamin C supplementation during gestation connected airway relation person not been assessed.
This multi-center randomized power proceedings conducted successful the United States included 251 large patients aged 15 years oregon older. Participants were existent smokers, defined arsenic having smoked ≥1 cigaret successful the past week, and were betwixt 13- and 22-weeks’ gestation. Patients were excluded if they had analyzable aesculapian conditions, were presently incarcerated, oregon had unstable methods of communication. 125 patients were randomized to person vitamin C (500mg/d) and 126 received placebo. The superior result was forced mid-expiratory travel (FEF25-75) measured by spirometry astatine property five. Secondary outcomes included forced expiratory measurement successful 1 2nd (FEV1) and self-reported oregon clinically recorded occurrence of wheeze betwixt 4 and 6 years old.
Results demonstrated that astatine 5 years old, children of large smokers who received vitamin C had improved airway function, demonstrated by improvements successful FEF25-75 and importantly decreased occurrence of wheeze, compared to the placebo group. This survey is constricted by imaginable misclassification of wheeze, which was assessed utilizing survey responses from a genitor oregon caretaker. However, the observed clinically important improvements and deficiency of adverse events associated with vitamin C supplementation aft a agelong follow-up play are precocious encouraging for the usage of vitamin supplementation successful large smokers. Further trials to find the optimal regimen and clip of supplementation during initiation is inactive needed.
Click to work the survey successful JAMA Pediatrics
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