CVD risk factors confer elevated risk for mortality in severe COVID-19 - Healio

CVD hazard factors were associated with mortality successful patients hospitalized for COVID-19, but preexisting CVD was not, researchers reported in Circulation: Cardiovascular Quality and Outcomes.

Further, myocardial injury, with oregon without CVD, was linked to accrued likelihood of decease oregon CV events successful this population, according to the researchers.

CVD hazard factors were associated with mortality successful patients hospitalized for COVID-19, but preexisting CVD was not.
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“The survey findings item that decease and cardiovascular complications of COVID-19 are related to the severity of the acute unwellness and the hyperinflammatory process alternatively than preexisting bosom disease,” Salim S. Hayek, MD, aesculapian manager of the University of Michigan Frankel Cardiovascular Center, told Healio.

For the multicenter cohort study, Hayek and colleagues evaluated 5,133 big patients who went to the ICU for COVID-19 from March to June 2020 to observe whether preexisting CVD was related to in-hospital mortality and CV events.

Researchers classified CVD arsenic preexisting CAD, congestive HF oregon atrial fibrillation/flutter.

Death occurring successful the infirmary wrong 28 days of admittance was the superior outcome, and secondary outcomes were CV events — specified arsenic cardiac arrest, new-onset arrhythmias, new-onset HF, myocarditis, pericarditis oregon changeable — wrong 14 days.

According to the researchers, 22.9% of patients had preexisting CVD. The mean property was 61 years, and 62.9% were men. Among the full cohort, 34.6% of patients died and 17.9% had a CV event.

When adjusted for aggregate variables and comorbidities, the OR for decease was 1.15 (95% CI, 0.98-1.34) successful patients with preexisting CVD.

“The relation was heavy attenuated erstwhile accounting for comorbidities, suggesting that cardiovascular hazard factors alternatively than CVD ... are the main contributors to in-hospital outcomes successful patients with terrible COVID-19,” the researchers wrote. “Indeed, age, BMI, smoking, hypertension and diabetes were the astir important contributors to mortality.”

There was nary autarkic narration betwixt preexisting CVD and CV events successful this population.

Additionally, careless of whether patients had CVD astatine admission, myocardial wounded was associated with higher likelihood of decease (adjusted OR = 1.93; 95% CI, 1.61-2.31) and CV events (aOR = 1.82; 95% CI, 1.47-2.24) successful the survey population, according to the researchers.

“These findings assistance clinicians counsel their patients connected their hazard of terrible COVID-19 corruption related to bosom disease,” Hayek told Healio. “[They also] use to the wide radical of patients with bosom disease. Patients who person much terrible forms of bosom illness who correspond a overmuch smaller proportionality of these patients should beryllium studied separately to much accurately find their risk.”

For much information:

Salim S. Hayek, MD, tin beryllium reached astatine shayek@med.umich.edu.